Heart attacks, strokes and other cardiovascular events represent the leading cause of death and disability among men and women in western societies. According to the American Heart Association's 2010 At-A-Glance Report, over 831,000 deaths in the United States were caused by heart disease and stroke, substantially more than the approximately 572,000 reported deaths caused by cancer . Cardiovascular disease encompasses many different diseases with patients often suffering from multiple conditions. It is estimated that total global pharmaceutical sales in the cardiovascular segment in 2010 were approximately $116.3 billion .
Hypertriglyceridemia refers to a condition in which patients have high levels of triglycerides (fats) in the bloodstream. Triglyceride levels provide important information as a marker associated with the risk for heart disease and stroke, especially when an individual also has low high-density lipoprotein cholesterol, or HDL-C (often referred to as "good" cholesterol), and elevated levels of LDL-C (often referred to as "bad" cholesterol). It is estimated that over 40 million adults in the United States have elevated triglyceride levels >200mg/dL and approximately 4 million adults in the United States have severe (>500 mg/dL) hypertriglyceridemia. In addition, it is estimated that 34 million adults in the United States have elevated triglyceride levels of >150 mg/dL to 199 mg/dL . In aggregate, approximately 70 million adults in the United States have elevated triglyceride levels. It is estimated that the worldwide number is at least three times the level in the United States . In the United States, mean triglyceride levels have risen since 1976 in concert with the growing epidemic of obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) [5,6]. In contrast, mean LDL-C levels have receded due to aggressive pharmacologic and dietary therapy .
Mixed dyslipidemia refers to a condition in which patients have a combination of two or more lipid abnormalities including elevated triglycerides, low HDL-C, and/or elevated LDL-C. Both hypertriglyceridemia and mixed dyslipidemia are components of a range of lipid disorders collectively referred to as dyslipidemia. Dyslipidemia has been linked to atherosclerosis, commonly referred to as hardening of the arteries.
1 American Cancer Society. Cancer Facts & Figures 2011. Atlanta: American Cancer Society, 2011
2 Urch Publishing. Cardiovascular Pharmaceutical Market Trends, 2007 to 2010. SKU URC1550232
3 Ford, Arch Intern Med. 2009; 169 (6): 572-578
5 Carroll MD, Lacher DA, Sorlie PD, Cleeman JI, Gordon DJ, Wolz M, Grundy SM,Johnson CL. Trends in serum lipids and lipoproteins of adults, 1960–2002. JAMA.2005; 294: 1773–1781.
6 Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999–2000. JAMA. 2002; 288: 1723–1727.
This page was last updated on July 20, 2012.