Expected volatility, maximum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
American Depositary Shares
American Depositary Share [Member]
American depositary share.
Description of lease agreement
Lessee, Operating Lease, Description
Employee Stock options, Vesting Period
Stock units, Vesting Period
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Segment and Geographical Information
Segment Reporting, Policy [Policy Text Block]
Gross margin
Gross Profit
Cash expenditures
Balance at December 31, 2020
Balance at December 31, 2021
Restructuring Reserve, Total
Certificate of Deposit
Certificates of Deposit [Member]
Regulatory Agency
Regulatory Agency [Axis]
Deferred Revenue Arrangement Type
Deferred Revenue Arrangement Type [Axis]
Restructuring Type [Axis]
Sales discount percentage
Cash Discount Percent
Cash discount percent.
Auditor Location
Interest receivable
Increase (Decrease) in Accrued Interest Receivable, Net
Operating expenses:
Operating Expenses [Abstract]
Tax credit carryforward expiration year
Tax Credit Carryforward Expiration Year
Tax credit carryforward expiration year.
Treasury Stock
Treasury Stock [Member]
Aggregate stock or cash payment upon potential market approval
Potential milestone payment upon marketing approval.
Potential Milestone Payment Upon Marketing Approval
Asset Class
Asset Class [Domain]
Operating income (loss)
Operating Income (Loss)
Bridgewater
Bridgewater [Member]
Bridgewater.
Corporate tax rate
Statutory Tax Rate
Statutory Tax Rate
Inventory, Finished Goods, Gross, Total
Finished goods
Inventory, Finished Goods, Gross
MARINE
Marine [Member]
Marine.
Concentration Risk Type
Concentration Risk Type [Domain]
Foreign currency loss
Foreign Currency Transaction Gain (Loss), Realized
Entity Emerging Growth Company
Entity Emerging Growth Company
Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Aggregate Intrinsic Value [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Aggregate Intrinsic Value [Abstract]
Income Tax Disclosure [Abstract]
Nonrefundable milestone payment received.
Nonrefundable Milestone Payment Receiveds
Non-refundable milestone payment received
Financial Instrument
Financial Instrument [Axis]
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Prepaid and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Available for future grant as of December 31, 2021
Ordinary shares, reserved and available for issuance
Available for future grant as of December 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Geographical
Geographical [Axis]
Common stock, 0.50 par, unlimited authorized; 404,084,775 shares issued, 396,598,008 shares outstanding at December 31, 2021; 398,425,000 shares issued, 392,538,081 shares outstanding at December 31, 2020
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common Stock, Value, Issued
Restricted Stock Unit Activity
Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Promotion fee as a percentage of gross margin
Percentage Of Gross Margin Payable For Promotion Agreement
Percentage of gross margin, payable for promotion agreement.
Liabilities
Total liabilities
Inventory, Raw Materials, Gross, Total
Raw materials
Inventory, Raw Materials, Gross
Components of Income (Loss) from Operations Before Taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Corscianto liquidation
Income Tax Reconciliation Liquidation
Income tax reconciliation liquidation.
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Valuation And Qualifying Accounts Disclosure [Line Items]
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Line Items]
Increase in intangible assets
Increase (Decrease) in Intangible Assets, Current
Initial recognition of operating lease right-of-use asset
Initial Recognition Of Operating Lease Right Of Use Asset
Initial recognition of operating lease right-of-use asset.
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures, Total
Vesting of restricted stock units
Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures
Taxes related to stock-based awards
Payment, Tax Withholding, Share-based Payment Arrangement
Class of Stock
Class of Stock [Domain]
Net operating loss carryback period
Net Operating Loss Carryback Period
Net operating loss carryback period.
Estimated Fair Value of Assets and Liability
Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]
Number of Shares
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Property, plant and equipment, Useful Life
Property, Plant and Equipment, Estimated Useful Lives
Cash
Charges Cash [Member]
Charges cash.
Legal Entity
Legal Entity [Axis]
Contributions made under defined contribution plan
Defined Contribution Plan, Employer Discretionary Contribution Amount
Debt Disclosure [Table]
Debt Disclosure [Table]
Debt disclosure.
Entity Address, Address Line Three
Entity Address, Address Line Three
Exercisable as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Entity Address, Country
Entity Address, Country
Compensation expense related to stock option
Stock or Unit Option Plan Expense
Product Revenue, Net
Product [Member]
Accounts receivable, net
Accounts receivable, net
Accounts Receivable, after Allowance for Credit Loss, Current
Go-to-Market Strategy
Go-to-Market Strategy [Member]
Restructuring
Costs incurred
Restructuring Charges
Restructuring Charges, Total
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Significant Accounting Policies
Significant Accounting Policies [Text Block]
Deferred revenue, Deductions
Revenue recognized related to upfront and milestone payments
Contract with Customer, Liability, Revenue Recognized
Other Liabilities, Current, Total
All other
Other Liabilities, Current
City Area Code
City Area Code
Assumptions Used to Estimate Fair Value of Share-Based Payment Awards
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Gross deferred tax assets
Deferred Tax Assets, Gross
Total deferred tax assets
Deferred Tax Assets, Net of Valuation Allowance
Weighted Average Grant-Date Fair Value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
U.S. Treasury Shares
US Treasury Securities [Member]
Change in accounting principle, accounting standards update, adopted [true false]
Forfeited
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Goodwill and Intangible Assets Disclosure [Abstract]
Contract with Customer, Liability, Total
Deferred revenue
Deferred revenue, Balance at Beginning of Period
Deferred revenue, Balance at End of Period
Contract with Customer, Liability
Commitments and contingencies (Note 8)
Commitments and Contingencies
Beginning balance
Ending balance
Valuation Allowances Provisions And Reserves Balance Net
Valuation allowances provisions and reserves balance net.
Anti-Dilutive Securities Not Included in the Computation of Net Earnings (Loss) per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Research and development credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Weighted Average Remaining Contractual Term
Share Based Compensation Arrangement By Share Based Payment Award Options Weighted Average Remaining Contractual Term [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Term [Abstract]
Finite-Lived Intangible Assets, Net, Beginning Balance
Finite-Lived Intangible Assets, Net, Ending Balance
Intangible asset, net
Intangible asset, net
Finite-Lived Intangible Assets, Net
2025
Finite-Lived Intangible Asset, Expected Amortization, Year Four
Deferred Revenue
Deferred Revenue [Domain]
Issuance of stock (shares)
Issuance of common stock, net of transaction costs (shares)
Stock Issued During Period, Shares, New Issues
Scenario
Scenario [Axis]
Purchase Obligation, Total
Potential payable amount over the agreement terms based on minimum purchase obligation
Purchase Obligation
Provision related to current period sales
SEC Schedule, 12-09, Valuation Allowances and Reserves, Additions, Charge to Cost and Expense
Lease Asset
Deferred Tax Liability Lease Asset
Deferred tax liability, lease asset.
Gross Product Sales
Revenue Benchmark [Member]
Tax return to provision adjustments
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount
Shares issued
Issuance of common stock under employee stock purchase plan (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Product expiration date after being converted into capsule form
Product Expiration Period Upon Conversion Into Capsule Form
Product expiration period upon conversion into capsule form.
Related Party
Related Party [Domain]
HLS
H L S Therapeutics Incorporation [Member]
HLS Therapeutics Incorporation.
Change in accounting principle, accounting standards update, immaterial effect [true false]
Amortization of Debt Issuance Costs and Discounts, Total
Interest expense, non-cash
Amortization of debt discount and debt issuance costs
Amortization of Debt Issuance Costs and Discounts
Conversion of Series A Convertible Preferred Stock, net
Stock Issued During Period, Value, Conversion of Convertible Securities
Restructuring
Restructuring Charges [Member]
Income Statement [Abstract]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Net cash provided by (used in) investing activities
Net Cash Provided by (Used in) Investing Activities
Debt
Debt Disclosure [Text Block]
Gross liabilities to expire in 2022
Deferred Tax Liabilities Subject To Expiration
Deferred Tax Liabilities, Subject to Expiration
Employee-related Liabilities, Current, Total
Payroll and payroll-related expenses
Employee-related Liabilities, Current
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property, plant and equipment, net
Property, plant and equipment, net
Property, Plant and Equipment, Net
Current deferred revenue
Contract with Customer, Liability, Current
Non-refundable milestone payment received
Nonrefundable Milestone Payment Received
Nonrefundable milestone payment received.
Common Stock, Shares, Issued, Total
Common stock, issued
Common Stock, Shares, Issued
Non-refundable up-front received period
Non Refundable Upfront Payments Received Period
Non refundable upfront payments received period.
Forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Deferred Tax Liabilities, Gross, Total
Total deferred tax liabilities
Deferred Tax Liabilities, Gross
American depositary shares conversion rate to preference shares
Preferred Stock, Conversion Basis
Operating lease right-of-use asset
Operating Lease, Right-of-Use Asset
Customer Concentration Risk
Customer Concentration Risk [Member]
Credits/payments made for prior period sales
Credits Payments Made For Prior Period Sales
Credits/payments made for prior period sales.
Revenue recognized in the period from:
Change in Contract with Customer, Liability [Abstract]
Name of each exchange on which registered
Security Exchange Name
Statistical Measurement
Statistical Measurement [Domain]
Other Incentives
Other Incentive Programs [Member]
Other incentive programs.
Furniture and Fixtures
Furniture and Fixtures [Member]
Other Liabilities, Noncurrent, Total
Other long-term liabilities
Other Liabilities, Noncurrent
Milestone payment achieved
Potential aggregate stock or cash payment
Milestone payment achieved.
Milestone Payment Achieved
ASU No. 2019-12
Finite-Lived Intangible Assets, Gross, Total
Technology rights
Finite-Lived Intangible Assets, Gross
Subsequent Event Type [Domain]
Regulatory Agency
Regulatory Agency [Domain]
Upfront payment
Non Refundable And Non Creditable Upfront Payment
Non-refundable and non-creditable upfront payment.
Debt Disclosure [Abstract]
Document Period End Date
Document Period End Date
Number of customers.
Number Of Customers
Number of customers
Income Statement Location
Income Statement Location [Axis]
Work in process
Inventory, Work in Process, Gross
Investments
Investments [Domain]
Summarizes the Aggregate Number of Stock Options And Restricted Stock Unit
Disclosure of Share-based Compensation Arrangements by Share-based Payment Award [Table Text Block]
Type of Restructuring [Domain]
Carry back net operating losses arising beginning year
Carry Back Net Operating Losses Arising Beginning Year
Carry back net operating losses arising beginning year.
Reconciliation of Total Amounts of Unrecognized Tax Benefits
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Current operating lease liability
Operating Lease, Liability, Current
Amortization of investments
Accretion (Amortization) of Discounts and Premiums, Investments
Related Party
Related Party [Axis]
Penalties related to uncertain tax positions
Unrecognized Tax Benefits, Income Tax Penalties Expense
Contract with Customer, Asset, after Allowance for Credit Loss, Total
Contract assets, Balance at Beginning of Period
Contract assets, Balance at End of Period
Contract with Customer, Asset, after Allowance for Credit Loss
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Maximum fair market value of stock which can be purchased by participant in calendar year
Share Based Compensation Arrangement By Share Based Payment Award Maximum F M V Of Shares Purchased Per Employee Calendar Yr
Share based compensation arrangement by share based payment award maximum fmv of shares purchased per employee calendar yr.
Class of Stock
Class of Stock [Axis]
Maximum co-promotion tail payments receive period
Maximum Co Promotion Tail Payments Receive Period
Maximum co-promotion tail payments receive period.
Jurisdictions the Company Remains Subject to Tax Examinations
Summary of Income Tax Examinations [Table Text Block]
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Net Operating Loss Carryback
Income Tax Reconciliation Net Operating Loss Carryback
Income tax reconciliation net operating loss carryback.
Concentration Risk Benchmark
Concentration Risk Benchmark [Domain]
Anti-dilutive securities
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Cumulative translation adjustment
Income Tax Rate Reconciliation Cumulative Translation Adjustment Amount
Income Tax Rate Reconciliation, Cumulative Translation Adjustment, Amount
Issuance of common stock for milestone payment (in shares)
Stock Issued During Period Shares Milestone Payment
Stock issued during period, shares, milestone payment.
VASCEPA 1-Gram
V A S C E P A One Gram [Member]
VASCEPA 1-gram.
Stock-based compensation
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-based Compensation Cost
Amounts to be received upon achievement of the regulatory milestone events
Eligible regulatory milestone events to be received.
Eligible Regulatory Milestone Events To be Received
Interest
Interest Paid, Excluding Capitalized Interest, Operating Activities
Interest
Taxes By Nature
Taxes By Nature [Axis]
Taxes by Nature [Axis]
Deferred tax liabilities:
Deferred Tax Liabilities, Net [Abstract]
Deferred tax assets:
Deferred Tax Assets, Net [Abstract]
Entity Address, Address Line Two
Entity Address, Address Line Two
Schedule of Inventory
Schedule of Inventory, Current [Table Text Block]
Current Fiscal Year End Date
Current Fiscal Year End Date
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Revenue recognized over remaining period
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Commitments And Contingencies Disclosure [Line Items]
Commitments And Contingencies Disclosure [Line Items]
Commitments and contingencies disclosure.
New Jersey Department of Treasury
New Jersey Division of Taxation [Member]
Net income (loss)-basic and diluted
Net Income Loss Available To Common Stockholders Basic And Diluted
Net income loss available to common stockholders basic and diluted.
Non-Trading Activity
Non Trading Activity [Member]
Non-Trading Activity [Member]
Preferred stock, equivalent ordinary shares upon future consolidation outstanding
Preferred Stock Equivalent Ordinary Shares Upon Future Conversion Outstanding
Preferred stock, equivalent ordinary shares upon future conversion outstanding.
License And Collaboration Agreements [Line Items]
License And Collaboration Agreements [Line Items]
License And Collaboration Agreements [Line Items]
Interest related to uncertain tax positions
Unrecognized Tax Benefits, Interest on Income Taxes Expense
Internal Revenue Service (IRS)
Internal Revenue Service (IRS) [Member]
Republic of Ireland and the United Kingdom
Ireland And United Kingdom [Member]
Republic of Ireland and the United Kingdom [Member]
Outstanding RSUs
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number, Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number, Beginning Balance
Restricted stock units, outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Outstanding, Number
Disaggregation Of Revenue [Table]
Disaggregation of Revenue [Table]
Counterparty Name
Counterparty Name [Axis]
ASSETS
Assets [Abstract]
Income Tax Authority, Name
Income Tax Authority, Name [Domain]
Total amount of unrecognized tax benefits that would affect the tax rate if recognized
Unrecognized Tax Benefits that Would Impact Effective Tax Rate
Ireland
IRELAND
Cash received (paid) during the year for:
Cash Paid During Period For [Abstract]
Cash Paid During Period For [Abstract]
Convertible senior notes, total ADS into which the debt is exchangeable
Conversion of Series A Convertible Preferred Stock, net (in shares)
Stock Issued During Period, Shares, Conversion of Convertible Securities
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Abstract]
Asset:
Assets, Fair Value Disclosure [Abstract]
2022
Lessee, Operating Lease, Liability, to be Paid, Year One
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Debt Instrument, Name
Debt Instrument, Name [Domain]
Accounts, Notes, Loans and Financing Receivable [Line Items]
Accounts, Notes, Loans and Financing Receivable [Line Items]
Common stock, par value
Common Stock, Par or Stated Value Per Share
Launch Date
Product Launch Year and Month
Product launch year and month.
Revenue Recognition
Revenue from Contract with Customer [Policy Text Block]
Benefit from Income Taxes
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Current year—increases
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Depreciation and amortization
Deferred Tax Liabilities Depreciation And Amortization
Deferred Tax Liabilities, Depreciation and Amortization
State
State and Local Jurisdiction [Member]
Weighted average shares outstanding-basic
Weighted Average Number of Shares Outstanding, Basic, Total
Basic
Balance (in shares)
Balance (in shares)
Shares, Outstanding
Income / (Loss) Before Taxes, Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Total current
Current Income Tax Expense (Benefit)
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Contract assets, Deductions
Contract With Customer Asset Deductions
Contract with Customer asset deductions.
BioPharma Debt
Biopharmaceutical [Member]
Biopharmaceutical.
Earliest Tax Year
Earliest Tax Year [Member]
Income (Loss) from operations before taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Document Type
Document Type
U.S. Federal
Domestic Tax Authority [Member]
Long-term inventory
Inventory, Noncurrent
Inventory, Noncurrent, Total
Deferred revenue, Additions
Contract With Customer Liability Additions
Contract with customer liability additions.
Long-term operating lease liability
Operating Lease, Liability, Noncurrent
SEC Schedule, 12-09, Valuation Allowances and Reserves, Amount, Ending Balance
SEC Schedule, 12-09, Valuation Allowances and Reserves, Amount, Beginning Balance
Valuation allowances and reserves
SEC Schedule, 12-09, Valuation Allowances and Reserves, Amount
Schedule of Accrued Expenses and Other Current Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Current assets
Total current assets
Assets, Current
Selling, General and Administrative Costs
Selling, General and Administrative Expenses, Policy [Policy Text Block]
Disaggregation Of Revenue [Line Items]
Disaggregation of Revenue [Line Items]
Stock-Based Compensation
Share-based Payment Arrangement [Policy Text Block]
Gross and net proceeds from stock option exercises
Proceeds from stock options exercised gross.
Proceeds From Stock Options Exercised Gross
Stock Options
Share-based Payment Arrangement, Option [Member]
United States—Federal
Deferred Federal Income Tax Expense (Benefit)
Outstanding as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Sales-based milestone event payment
Eligible sales based milestone events to be received.
Eligible Sales Based Milestone Events To be Received
Ordinary Shares Basis
Ordinary Shares Basis [Member]
Ordinary shares basis.
Proceeds from Sale and Maturity of Marketable Securities, Total
Sale and maturities of securities
Proceeds from Sale and Maturity of Marketable Securities
Provision for income taxes
Provision for income taxes
Income Tax Expense (Benefit)
Supplemental disclosure of non-cash transactions:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Restructuring Reserve [Roll Forward]
Leases [Abstract]
Antidilutive Securities
Antidilutive Securities [Axis]
Performance-Based RSUs
Performance Based Restricted Stock Units [Member]
Performance-based restricted stock units.
Approval Date
Product Approval Year and Month
Product approval year and month.
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Beginning Balance
Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Accounts payable, accrued expenses and other current liabilities
Increase (Decrease) in Accounts Payable and Other Operating Liabilities
Stock Incentive Plan 2020
Stock Incentive Plan Twenty Twenty [Member]
Stock incentive plan Twenty Twenty.
Long-term debt from royalty-bearing instrument
Income Tax Reconciliation Long Term Debt Royalty Bearing Instrument
Income tax reconciliation long term debt royalty bearing instrument.
Vested and expected to vest as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Deferred Tax Assets, Operating Loss Carryforwards, Total
Net operating losses
Deferred Tax Assets, Operating Loss Carryforwards
Locations
Locations [Domain]
Locations [Domain]
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, outstanding
Common Stock, Shares, Outstanding
United States—State
Current State and Local Tax Expense (Benefit)
Plan Name
Plan Name [Axis]
Finite-Lived Intangible Assets [Line Items]
Finite-Lived Intangible Assets [Line Items]
Maturities period
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
SEC Schedule, 12-09, Valuation Allowances and Reserves Type
SEC Schedule, 12-09, Valuation Allowances and Reserves Type [Axis]
Forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Total deferred
Deferred Income Tax Expense (Benefit)
Total operating expenses
Operating Expenses
Valuation And Qualifying Accounts Disclosure [Table]
SEC Schedule, 12-09, Valuation and Qualifying Accounts Disclosure [Table]
Current:
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Inventory
Inventory
Inventory, Net
Weighted average shares outstanding:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Financial Instruments
Financial Instruments [Domain]
Preferred Stock
Preferred Shares
Preferred Stock [Member]
Outstanding as of December 31, 2021
Outstanding as of January 1, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Deferred:
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Other liabilities
Deferred Tax Liabilities, Other
Maturity Analysis of Undiscounted Payments for Operating Lease Liabilities and Reconciliation with Carrying Amount of Lease Liability
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Net earnings (loss) per share-diluted
Earnings Per Share, Diluted, Total
Diluted
Customer A
Customer A [Member]
Customer A.
Earnings Per Share [Abstract]
2023
Lessee, Operating Lease, Liability, to be Paid, Year Two
Net income (loss)
Income for the period
Income (loss) for the period
Net Income (Loss) Attributable to Parent
Difference between Benefit from Income Taxes and Amount Computed by Applying Statutory Income Tax Rate to Income Before Taxes
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Concentration of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Defined Contribution Plan
Compensation and Employee Benefit Plans [Text Block]
Business Development
Business Development [Domain]
Business Development [Domain]
Incremental borrowing rate for purposes of calculation of lease liabilities
Operating Lease, Weighted Average Discount Rate, Percent
Research and Development Expense
Research and Development
Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures, Total
Stock options, Granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures
Document Fiscal Period Focus
Document Fiscal Period Focus
Number of renewal options
Number Of Renewal Options
Number of renewal options.
Accounting Policies [Abstract]
Foreign
Current Foreign Tax Expense (Benefit)
Co-Promotion Agreement
Co Promotion Agreement [Member]
Co promotion agreement.
Entity Address, Address Line One
Entity Address, Address Line One
Intrinsic value of options exercised
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Outstanding as of December 31, 2021
Outstanding as of January 1, 2021
Outstanding Stock Options
Stock options, outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Asset Backed Securities
Asset-backed Securities [Member]
Total current liabilities
Liabilities, Current
Accumulated amortization
Finite-Lived Intangible Assets, Accumulated Amortization
Money market instruments.
Money Market Instruments
Money Market Instruments [Member]
Stockholders Equity Note [Line Items]
Stockholders Equity Note [Line Items]
Stockholders Equity Note [Line Items]
Net income (loss)
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Commercial Paper
Commercial Paper [Member]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Title of Individual
Title of Individual [Axis]
Balance, Treasury Shares (in shares)
Balance, Treasury Shares (in shares)
Treasury Stock, Shares, Total
Treasury stock, shares
Treasury Stock, Shares
Shares retained for settlement of employee tax obligations
Treasury shares for settlement of employee tax obligations
Share-based Payment Arrangement, Shares Withheld for Tax Withholding Obligation
Risk free interest rate, maximum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Contract assets, Additions
Contract With Customer Assets Additions
Contract with customer assets additions.
Outstanding as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Rent payment
Total undiscounted payments
Lessee, Operating Lease, Liability, to be Paid
Product and Service
Product and Service [Domain]
Accrued Liabilities and Other Liabilities, Total
Accrued expenses and other liabilities
Accrued Liabilities and Other Liabilities
Commitments And Contingencies Disclosure [Table]
Commitments And Contingencies Disclosure [Table]
Commitments and contingencies disclosure.
Lease termination existence of option to extend
Lessee, Operating Lease, Existence of Option to Terminate [true false]
Stock option/RSU windfall (shortfall)
Income Tax Reconciliation Windfall Tax Benefit Shortfall
Income tax reconciliation windfall tax benefit (shortfall).
Intangible Asset
Intangible Assets Disclosure [Text Block]
Summary of Product Approval
Summary of Product Approval [Table Text Block]
Summary of product approval.
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Further Indication for AMR101
Further Indication For A M R One Zero One [Member]
Further indication for AMR101.
Other long-term liabilities
Increase (Decrease) in Other Noncurrent Liabilities
Rebates, Chargebacks and Discounts
Rebates Chargebacks And Discounts [Member]
Rebates chargebacks and discounts.
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Unusual Risk or Uncertainty, Nature
Unusual Risk or Uncertainty, Nature [Axis]
Equity Components
Equity Components [Axis]
Proceeds from Issuance of Long-term Debt, Total
Amount received at the closing of the agreement
Proceeds from Issuance of Long-term Debt
Tax Period
Tax Period [Axis]
Current Assets:
Assets, Current [Abstract]
Business Developments
Business Developments [Axis]
Business Developments [Axis]
Restricted Cash and Cash Equivalents, Current, Total
Restricted cash
Restricted Cash and Cash Equivalents, Current
Edding
Edding [Member]
Edding.
Co Promotion Agreement [Line Items]
Co Promotion Agreement [Line Items]
Co-promotion agreement.
Entity Registrant Name
Entity Registrant Name
Percentage of fair market value to payroll deductions to eligible employees to purchase ordinary shares
Share-based Compensation Arrangement by Share-based Payment Award, Discount from Market Price, Purchase Date
Latest Tax Year
Latest Tax Year [Member]
Series A Preferred Stock
Series A Preferred Stock [Member]
Equity
Stockholders' Equity Note Disclosure [Text Block]
Entity Interactive Data Current
Entity Interactive Data Current
Contract liabilities:
Contract with Customer, Liability [Abstract]
Entity Address, City or Town
Entity Address, City or Town
Customer
Customer [Axis]
Mochida
Mochida Pharmaceutical Co Ltd [Member]
Mochida Pharmaceutical Co., Ltd.
Accounts Receivable
Accounts Receivable [Member]
Preferred Shares Basis
Preferred Shares Basis [Member]
Preferred shares basis.
Compensation expense in relation to restricted stock units
Restricted Stock or Unit Expense
Expected volatility, minimum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
United Arab Emirates
UNITED ARAB EMIRATES
Stock options, additional granted
Share Based Compensation Arrangement By Share Based Payment Award Options Additional Grants In Period
Share based compensation arrangement by share based payment award options additional grants in period.
Expected option life (years)
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Trading Symbol
Trading Symbol
Effect of dilutive securities
Incremental Common Shares Attributable to Share-based Payment Arrangements, Total
Other
Other Country [Member]
Other country.
CASH FLOWS FROM INVESTING ACTIVITIES:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Document And Entity Information [Line Items]
Document And Entity Information [Line Items]
Document and entity information.
Discount Adjustments
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Concentration Risk Type
Concentration Risk Type [Axis]
Intangible Asset, net
Intangible Assets, Finite-Lived, Policy [Policy Text Block]
Inventory
Inventory, Policy [Policy Text Block]
Short Term Investments
Short-term Investments [Member]
Local Phone Number
Local Phone Number
Schedule of Carrying Value of Intangible Asset
Schedule of Finite-Lived Intangible Assets [Table Text Block]
Total stockholders’ equity
Balance
Balance
Stockholders' Equity Attributable to Parent
Amarin Pharmaceuticals Ireland Limited
Amarin Pharmaceuticals Ireland Limited [Member]
Amarin Pharmaceuticals Ireland Limited [Member]
Marketing Approval In Europe
Marketing Approval In Europe [Member]
Marketing approval in Europe.
Subsequent Event Type [Axis]
Weighted Average Exercise Price
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Beginning uncertain tax benefits
Ending uncertain tax benefits
Unrecognized Tax Benefits
Change in valuation reserves
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Debt Disclosure [Line Items]
Debt Disclosure [Line Items]
Debt disclosure.
CPPIB
C P P I B [Member]
CPPIB.
Qatar
QATAR
Repayments of Long-term Debt, Total
Payment on debt from royalty-bearing instrument
Repayments of Long-term Debt
Asset, fair value
Assets, Fair Value Disclosure
Estimated offering expense
Equity Offering Costs
Equity offering costs.
Decrease in net operating loss carryforwards from prior years
Decrease in net operating loss carryforwards from prior years
Deferred Tax Assets Operating Loss Carryforwards Change In Amount
Deferred Tax Assets, Operating Loss Carryforwards, Change In Amount
Statistical Measurement
Statistical Measurement [Axis]
Entity Small Business
Entity Small Business
Deferred Tax Assets, Tax Credit Carryforwards, Total
Tax credit carryforwards
Tax credits
Deferred Tax Assets, Tax Credit Carryforwards
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Interest expense, contractual coupon interest
Interest Expense, Debt, Excluding Amortization
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Milestones payment
Payment Of Milestones
Payment of milestone.
Income Tax Effect of Each Type of Temporary Difference Comprising Net Deferred Tax Asset
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Long-Lived Asset Impairment
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Product Returns
Product Returns [Member]
Product returns.
Restructuring Plan [Axis]
Property, plant and equipment, Useful Life
Property, Plant and Equipment, Useful Life
Entity
Entity [Domain]
U.S., Republic of Ireland, United Kingdom and Israel
Domestic Country Republic Of Ireland United Kingdom And Israel [Member]
Domestic Country, Republic of Ireland, United Kingdom and Israel [Member]
New York State Department of Taxation and Finance
Additional Paid in Capital, Ending Balance
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Total
Additional paid-in capital
Additional Paid in Capital
ASU No. 2016-09
Accounting Standards Update 2016-09 [Member]
Use of Forecasted Financial Information in Accounting Estimates
Use Of Forecasted Financial Information In Accounting Estimates Policy [Text Block]
Use of forecasted financial information in accounting estimates.
Accrued co- promotion tail payments
Accrued Co Promotion Tail Payments
Accrued co promotion tail payments.
Granted
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Co-promotion tail payments payable
Co promotion tail payments payable.
Co Promotion Tail Payments Payable
Clinical Trial Application
Clinical Trial Application [Member]
Clinical trial application.
Permanent and other
Effective Income Tax Rate Reconciliation, Other Adjustments, Amount
Provision related to prior period sales
Provision Related To Prior Period Sales
Provision related to prior period sales.
Equity [Abstract]
Bahrain
BAHRAIN
Expired
Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price
Revenue from Contract with Customer [Abstract]
Plan Name
Plan Name [Domain]
Lessee Lease Description [Table]
Lessee, Lease, Description [Table]
Number of sales representatives
Number of sales representatives.
Income Tax Authority
Income Tax Authority [Axis]
Depreciation, Total
Depreciation expense
Depreciation
Lease agreement term
Lessee, Operating Lease, Term of Contract
Increase as reflected in income tax expense
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Amortization of Intangible Assets, Total
Amortization of intangible asset
Amortization of Intangible Assets
Depreciation and amortization
Depreciation And Amortization Excluding Amortization Of Intangible Assets
Depreciation and amortization excluding amortization of intangible assets.
Other reserves and accrued liabilities
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Reserves
Laxdale Milestone Shares
Laxdale milestone shares.
Stock issued under private placement, value
Issuance of common stock, net of transaction costs
Stock Issued During Period, Value, New Issues
Credits/payments made for current period sales
SEC Schedule, 12-09, Valuation Allowances and Reserves, Deduction
Carry back net operating losses arising end year
Carry Back Net Operating Losses Arising End Year
Carry back net operating losses arising end year.
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]
Chargebacks
Allowance For Estimated Chargebacks [Member]
Allowance for Estimated Chargebacks [Member]
Customer B
Customer B [Member]
Customer B.
Interest Expense, Total
Interest expense
Interest Expense
Tax Years
Open tax year
Open Tax Year
Costs for Patent Litigation and Legal Proceedings
Legal Costs, Policy [Policy Text Block]
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation expense
Stock-based compensation
Share-based Payment Arrangement, Noncash Expense
Prepaid and other current assets
Prepaid Expense and Other Assets, Current
Health Canada
Health Canada [Member]
Health, Canada.
Issuance of common stock for milestone payment
Stock Issued During Period Value Milestone Payment
Stock issued during period, value, milestone payment.
Stock Option Activity
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Related Party Transactions [Abstract]
Debt outstanding
Long-term Debt, Gross
Inventory Disclosure [Abstract]
Common shares issued in settlement of RSUs and Performance Based RSUs vested
Shares Issued, Shares, Share-based Payment Arrangement, after Forfeiture, Total
Shares issued, related to the vesting of RSUs
Shares Issued, Shares, Share-based Payment Arrangement, after Forfeiture
Accrued revenue allowances
Accrued Liabilities Sales Allowances Current
Accrued Liabilities Sales Allowances Current
United States—Federal
Current Federal Tax Expense (Benefit)
Summary of Equity Awards Activity
Share-based Payment Arrangement, Activity [Table Text Block]
2027 and thereafter
Lessee Operating Lease Liability Payments Due Year Six And Thereafter
Lessee operating lease liability, payments due, year six and thereafter.
Long-term Debt, Current Maturities, Total
Outstanding debt
Debt from royalty-bearing instrument
Long-term Debt, Current Maturities
Cash and liquid short-term and long-term investments
Cash And Liquid Short Term And Long Term Investments
Cash and liquid short-term and long-term investments.
Co Promotion Agreement [Table]
Co Promotion Agreement [Table]
Co-promotion agreement.
Exercisable as of December 31, 2021
Exercisable as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Net cash (used in) provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Percentage of payroll deductions to eligible employees to purchase ordinary shares
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Employee Subscription Rate
Commitments and Contingencies Disclosure [Abstract]
Vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
TOTAL ASSETS
Total assets
Assets
Level 2
Fair Value, Inputs, Level 2 [Member]
% of Outstanding Shares
Percentage of outstanding shares on a fully diluted basis
Percentage Of Outstanding Common Shares And Preferred Shares On Fully Diluted Basis
Percentage of outstanding common shares and preferred shares on fully diluted basis.
Leases
Lessee, Operating Leases [Text Block]
Common shares issued for stock option exercises
Exercised
Exercise of stock options (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Number of indications of the regulatory milestone events relating to the submission and approval
Number Of Regulatory Milestone Events Indications
Number of regulatory milestone events indications.
Statement [Line Items]
Statement [Line Items]
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY
Liabilities and Equity
2023
Finite-Lived Intangible Asset, Expected Amortization, Year Two
Property, Plant and Equipment [Abstract]
Statement of Cash Flows [Abstract]
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Communication costs related to direct-to-consumer activities
Communication costs pertaining to marketing commitments.
Communication Costs Pertaining to Marketing Commitments
Title of each class
Title of 12(b) Security
Allowance for doubtful account.
Allowance for Doubtful Accounts
Allowance For Doubtful Account [Member]
Concentration of Suppliers
Concentration Of Suppliers Policy [Text Block]
Concentration of suppliers.
Level 3
Fair Value, Inputs, Level 3 [Member]
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Award Type
Award Type [Domain]
Non-refundable up-front received
Non Refundable Upfront Payments Received
Non refundable upfront payments received.
Kuwait
KUWAIT
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Expire period
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period
Interest income
Investment Income, Interest
Disposal (purchase) of furniture, fixtures and equipment
Disposal (purchase) of furniture, fixtures and equipment.
Disposal (Purchase) of Furniture, Fixtures and Equipment
Non-US Government
Debt Security, Government, Non-US [Member]
Intangible asset estimated weighted- average remaining useful life
Finite-Lived Intangible Assets, Remaining Amortization Period
Property, Plant and Equipment
Property, Plant and Equipment [Table Text Block]
Level 1
Fair Value, Inputs, Level 1 [Member]
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total
Vesting of restricted stock units (in shares)
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures
2025
Lessee, Operating Lease, Liability, to be Paid, Year Four
Net deferred tax assets
Deferred Tax Assets, Net
VASCEPA 0.5-Gram
V A S C E P A Half Gram [Member]
VASCEPA 0.5-gram.
Corporate Bonds
Corporate Debt Securities [Member]
Vested and expected to vest as of December 31, 2021
Vested and expected to vest as of December 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Accounts Receivable, net
Receivable [Policy Text Block]
Granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Entity Current Reporting Status
Entity Current Reporting Status
Development, Commercialization and Supply Agreements
Collaborative Arrangement Disclosure [Text Block]
Revenue Recognition
Revenue from Contract with Customer [Text Block]
Investment Type
Investment Type [Axis]
License And Collaboration Agreements [Table]
License And Collaboration Agreements [Table]
License And Collaboration Agreements [Table]
Payments to Acquire Marketable Securities, Total
Purchases of securities
Payments to Acquire Marketable Securities
Entity Voluntary Filers
Entity Voluntary Filers
Risk free interest rate, minimum
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Scenario
Scenario [Domain]
Money Market Fund
Money Market Funds [Member]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Earnings (Loss) per Share
Earnings Per Share, Policy [Policy Text Block]
Gross trade accounts receivable
Accounts Receivable, before Allowance for Credit Loss, Current
Stock-Based Compensation Expense Related to Option Awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Retirement Benefits [Abstract]
Computer equipment
Computer Equipment [Member]
United States—State
Deferred State and Local Income Tax Expense (Benefit)
VASCEPA.
VASCEPA
VASCEPA [Member]
Selling, general and administrative
Selling, General and Administrative Expenses [Member]
Auditor Firm ID
Trade Allowances
SEC Schedule, 12-09, Allowance, Credit Loss [Member]
Income Statement Location
Income Statement Location [Domain]
United States
UNITED STATES
Accrued interest payable
Increase (Decrease) in Interest Payable, Net
Auditor Name
Provisions benefit for income taxes
Employee Service Share Based Compensation Tax Benefit Deficiency Realized From Exercise Of Stock Options
Employee service share based compensation tax benefit (deficiency) realized from exercise of stock options.
Net earnings (loss) per share-basic
Earnings Per Share, Basic, Total
Basic
Restructuring
Potential Marketing Approval 2
Potential Marketing Approval Two [Member]
Potential marketing approval 2.
Taxes By Nature
Taxes By Nature [Domain]
Taxes by Nature [Domain]
CARES Act
C A R E S Act [Member]
CARES Act.
Exercisable as of December 31, 2021
Exercisable as of December 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Federal
Federal [Member]
Federal [Member]
Change in Restructuring Liability Associated with the Plan
Common stock, shares authorized, unlimited
Common Stock, Shares Authorized, Unlimited [Fixed List]
Minimum
Minimum [Member]
Vested and expected to vest as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Measurement Frequency
Measurement Frequency [Domain]
Location
Location [Axis]
Location [Axis]
Exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Plans
Stock Incentive Plan Twenty Twenty And Stock Incentive Plan Twenty Eleven [Member]
Stock incentive plan 2020 and stock incentive plan 2011.
Unusual Risk or Uncertainty, Nature
Unusual Risk or Uncertainty, Nature [Domain]
One-time Termination Benefits
Food and Drug Administration
Food And Drug Administration [Member]
Food and drug administration.
REDUCE-IT
Reduce IT [Member]
REDUCE-IT.
Granted
Stock units, Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
2022
Finite-Lived Intangible Asset, Expected Amortization, Year One
ISO disqualifying disposition windfall
Income Tax Reconciliation Disqualifying Disposition Windfall
Income tax reconciliation disqualifying disposition windfall.
Valuation Allowance
Summary of Valuation Allowance [Table Text Block]
Undiscounted lease payments
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
Nature of Business and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Foreign net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Foreign
Document Annual Report
Document Annual Report
State
State [Member]
State [Member]
Deferred Tax Assets, Valuation Allowance, Total
Less: valuation allowance
Beginning valuation allowance
Ending valuation allowance
Deferred Tax Assets, Valuation Allowance
Change in incremental borrowing rate
Operating Lease Change In Weighted Average Discount Rate Percent
Operating lease change in weighted average discount rate percent.
Effect of significant financing component when transfer and customer payment of good or service occurs within one year or less
Revenue, Practical Expedient, Financing Component [true false]
CASH FLOWS FROM FINANCING ACTIVITIES:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Unrecognized stock-based compensation expense related to unvested stock option
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Income Taxes [Line Items]
Income Tax [Line Items]
Income tax.
United States
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Debt Instrument
Debt Instrument [Axis]
Foreign Currency
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Entity Filer Category
Entity Filer Category
Income Taxes
Income Tax, Policy [Policy Text Block]
Document Fiscal Year Focus
Document Fiscal Year Focus
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Vested and expected to vest as of December 31, 2021
Vested and expected to vest as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Rate differential
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount
Schedule of Estimated Future Amortization Expense
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Weighted average fair value of the stock options granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Ending Balance
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Income Taxes
Income Tax Disclosure [Text Block]
2017 Employee Stock Purchase Plan
Two Thousand And Seventeen Employee Stock Purchase Plan [Member]
Two thousand and seventeen employee stock purchase plan.
Licensing and royalty.
Licensing and Royalty Revenue
Licensing And Royalty [Member]
Co-Promotion Agreement
Co Promotion Agreement Disclosure [Text Block]
Co promotion agreement disclosure.
Property, Plant and Equipment
Property, Plant and Equipment Disclosure [Text Block]
Schedule Of Accounts Notes Loans And Financing Receivable [Table]
Schedule of Accounts, Notes, Loans and Financing Receivable [Table]
Maximum
Maximum [Member]
Changes in Balances of Contract Assets and Liabilities and Revenues Recognized
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Entity Central Index Key
Entity Central Index Key
Cash and Cash Equivalents and Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Other
Payables and Accruals [Abstract]
Operating Lease, rent
Operating lease expense
Costs incurred
Restructuring Costs Incurred
Restructuring costs incurred.
Kowa Pharmaceuticals America, Inc.
Kowa Pharmaceuticals America Incorporation [Member]
Kowa Pharmaceuticals America Incorporation.
Benefits from taxes at statutory rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Accrued expenses and other current liabilities
Accrued expenses and other current liabilities
Accrued Liabilities And Other Liabilities Current
Accrued liabilities and other liabilities current.
SEC Schedule, 12-09, Valuation Allowances and Reserves
SEC Schedule, 12-09, Valuation Allowances and Reserves [Domain]
Entity Tax Identification Number
Entity Tax Identification Number
Equity Component
Equity Component [Domain]
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Laxdale milestone
Non Cash Or Part Non Cash Milestone Payment
Non cash or part non cash, milestone payment.
SEC Schedule, 12-09, Valuation Allowances and Reserves, Period Increase (Decrease), Total
Change in valuation allowance
SEC Schedule, 12-09, Valuation Allowances and Reserves, Period Increase (Decrease)
Income Tax Authority
Income Tax Authority [Domain]
Revenue recognition period of non-refundable up-front payment
Deferred Revenue Recognition Period
Estimated number of days following the end of the quarter before related revenue is recognized.
Accrued Expenses and Other Current Liabilities
Accrued Expenses And Other Liabilities Disclosure [Text Block]
Discloses the breakout of accrued expenses and other liabilities that are not individually material for a separate caption on the statement of financial position between the current portion (payable within 12 months of year end or the operating cycle) and non-current (payable after 12 months from year end).
Unrecognized stock-based compensation expense related to unvested stock option, recognition period
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Lease Liability
Deferred Tax Asset Lease Liability
Deferred tax asset lease liability.
Performance obligations satisfied in previous periods
Contract with Customer, Performance Obligation Satisfied in Previous Period
Tax reserves
Income Tax Reconciliation Tax Reserve
Income tax reconciliation tax reserve.
Restructuring Plan [Domain]
Unrecognized deferred income tax liability
Deferred Tax Liability Not Recognized, Amount of Unrecognized Deferred Tax Liability, Undistributed Earnings of Foreign Subsidiaries
Accounts receivable, net
Increase (Decrease) in Accounts Receivable
Change in accounting principle, accounting standards update, adoption date
Adjustments
Adjustment
Leasehold improvements
Leasehold Improvements [Member]
Number of shares
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Document And Entity Information [Table]
Document And Entity Information [Table]
Document and entity information table.
Concentration risk percentage
Licensing Revenue
License [Member]
Statement [Table]
Statement [Table]
Selling, General and Administrative Expense, Total
Selling, general and administrative
Selling, General and Administrative Expense
Entity File Number
Entity File Number
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Other Commitment, Total
Maximum repayment of future revenue and receivables
Other Commitment
Lessee Lease Description [Line Items]
Lessee, Lease, Description [Line Items]
Other long-term assets
Increase (Decrease) in Other Noncurrent Assets
Accumulated Deficit
Retained Earnings [Member]
Accounting Standards Update
Accounting Standards Update [Domain]
Accounting Standards Update
Accounting Standards Update [Axis]
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Licenses revenue
Total revenue, net
Revenue from Contract with Customer, Excluding Assessed Tax
Payment of transaction costs for conversion of preferred stock
Payments of Stock Issuance Costs
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Potential Marketing Approval 1
Potential Marketing Approval One [Member]
Potential marketing approval 1.
Repo securities.
Repo Securities
Repo Securities [Member]
Inventory
Inventory Disclosure [Text Block]
Current Liabilities:
Liabilities, Current [Abstract]
Stock Incentive Plans and Stock-Based Compensation
Share-based Payment Arrangement [Text Block]
Cumulative translation adjustment
Valuation Allowances And Reserves Foreign Currency Translation
Valuation Allowances And Reserves Foreign Currency Translation
Long term investments.
Long Term Investments
Long Term Investments [Member]
Subsequent Event
Subsequent Event [Member]
Earnings (loss) per share:
Loss per share:
Earnings Per Share, Basic and Diluted [Abstract]
Commitments and Contingencies
Commitments and Contingencies Disclosure [Text Block]
Operating Lease, Liability, Total
Operating lease liability
Operating Lease, Liability
Payments
Payments for Restructuring
2024
Finite-Lived Intangible Asset, Expected Amortization, Year Three
Common Shares
Common Stock [Member]
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property, plant and equipment
Property, Plant and Equipment, Gross
Proceeds from issuance of common stock under employee stock purchase plan
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Excluding Option Exercised
Entity Public Float
Entity Public Float
Expired
Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period
Cover [Abstract]
Beginning Balance
Ending Balance
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Asset Class
Asset Class [Axis]
Statement of Stockholders' Equity [Abstract]
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Number of operating segments
Number of Operating Segments
Short term lease period
Short Term Lease Period
Short term lease period.
Share-based Payment Arrangement [Abstract]
Nondeductible employee compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Payment Arrangement, Amount
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Ordinary Shares
Ordinary Shares [Member]
Ordinary shares.
Lease commencement date
Operating Lease Commencement Date
Operating lease commencement date.
Restricted Stock and Restricted Stock Units
Restricted Stock Units (RSUs)
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Document Transition Report
Document Transition Report
Stockholders Equity Note [Table]
Stockholders Equity Note [Table]
Stockholders Equity Note [Table]
Proceeds from the exercise of options
Proceeds from exercise of stock options, net of transaction costs
Proceeds from Stock Options Exercised
United Kingdom
UNITED KINGDOM
Change in Contract with Customer, Asset and Liability [Abstract]
Lease renewal term
Lessee, Operating Lease, Renewal Term
Ireland and United Kingdom
Deferred Foreign Income Tax Expense (Benefit)
Additional upfront payment eligible to receive based on development, regulatory and sales Milestone
Additional milestone payments to be received.
Additional Milestone Payments To be Received
Distribution Costs
Distribution Costs Related To Shipping Product Policy [Text Block]
Distribution costs related to shipping product.
Stock Incentive Plan 2020 and 2011
Stock Incentive Plan Twenty Twenty And Twenty Eleven [Member]
Stock Incentive Plan 2020 and 2011.
Research and Development Expense, Total
Research and development
Research and Development Expense
Trading Activity
Trading Activity [Member]
Trading Activity [Member]
Long-term deferred revenue
Contract with Customer, Liability, Noncurrent
Weighted average shares outstanding-diluted
Weighted average shares outstanding-diluted
Diluted
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Significant accounting policies.
Cost of Goods and Services Sold, Total
Less: Cost of goods sold
Cost of Goods and Services Sold
2026
Finite-Lived Intangible Asset, Expected Amortization, Year Five
In-licenses
In Licenses Agreement [Member]
In-licenses agreement.
Royalty-Bearing Debt
Royalty Bearing Debt [Member]
Royalty-bearing debt.
Out-licenses
Out Licenses Agreement [Member]
Out-licenses agreement.
Income Tax [Table]
Income Tax [Table]
Income tax.
Concentration Risk Benchmark
Concentration Risk Benchmark [Axis]
Statement of Financial Position [Abstract]
Co Promotion Agreement [Abstract]
Co-promotion agreement.
Expected dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Vested
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Share conversion price
Conversion Price Per Share
Conversion price per share.
Summary of Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable Balances
Schedule of Accounts, Notes, Loans and Financing Receivable [Table Text Block]
Zug
Zug [Member]
Zug.
2026
Lessee, Operating Lease, Liability, to be Paid, Year Five
Employees
Employees [Member]
Employees member.
Stockholders’ Equity:
Stockholders' Equity Attributable to Parent [Abstract]
Prior year—decreases
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Summarize Activity of the Net Product Revenue Allowance and Reserve Categories
Summary Of Net Product Revenue Valuation Allowances Table [Text Block]
Summary of net product revenue valuation allowances.
Lebanon
LEBANON
Long-term Investments, Total
Long-term investments
Long-term Investments
Calculation of Net Income (Loss) and Number of Shares Used to Compute Basic and Diluted Net Earnings (Loss) per Share
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Exercised
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Increase (Decrease) in Inventories, Total
Inventory
Increase (Decrease) in Inventories
Changes in assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Inventory
Inventory Current and Non-current
Inventory current and non-current.
2024
Lessee, Operating Lease, Liability, to be Paid, Year Three
Software
Software Development [Member]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Lease termination description
Lessee, Operating Lease, Option to Terminate
Reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Measurement Frequency
Measurement Frequency [Axis]
Award Type
Award Type [Axis]
Entity Shell Company
Entity Shell Company
Sale of stock price per share
Sale of Stock, Price Per Share
Sales and marketing accruals
Accrued Marketing Costs, Current
LIABILITIES AND STOCKHOLDERS’ EQUITY
Liabilities and Equity [Abstract]
Income Tax Authority, Name
Income Tax Authority, Name [Axis]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Issuance of common stock under employee stock purchase plan
Stock Issued During Period, Value, Employee Stock Purchase Plan
Thereafter
Finite-Lived Intangible Asset, Expected Amortization, after Year Five
Non Cash
Non Cash [Member]
Non-cash.
Counterparty Name
Counterparty Name [Domain]
Long-Term Liabilities:
Liabilities, Noncurrent [Abstract]
Shares
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Amendment Flag
Amendment Flag
Amounts included in contract liability at the beginning of the period
Amounts included in contract liability at the beginning of the period
Contract With Customer Liability Revenue Recognized Excluding Performance Obligation Satisfied In Previous Period
Contract with customer liability revenue recognized excluding performance obligation satisfied in previous period.
Product and Service
Product and Service [Axis]
Conversion of Series A Convertible Preferred Stock into common stock
Conversion of Stock, Amount Converted
Schedule Of Finite Lived Intangible Assets [Table]
Schedule of Finite-Lived Intangible Assets [Table]
Short-term Investments, Total
Short-term Investments
Short-term investments
Other (expense) income, net
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Grant date fair value of options vested
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value
Office Space
Office Space [Member]
Office space.
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Title of Individual
Title of Individual [Domain]
Undistributed earning retained indefinitely for reinvestment by foreign subsidiary
Undistributed Earnings of Foreign Subsidiaries
Agency security.
Agency Securities
Agency Security [Member]
Operating lease, liability, current, statement of financial position [Extensible List]
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Unrealized gain (loss) on held-to-maturity securities
Held to maturity securities continuous unrealized gain (loss) position fair value.
Held To Maturity Securities Continuous Unrealized Gain Loss Position Fair Value
Unrealized gain (loss) on held-to-maturity securities
Income taxes
Income Taxes Paid, Net
Income Taxes Paid, Net, Total
Biologix FZCo
Biologix [Member]
Biologix [Member]
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Fair Value, Measurements, Recurring
Fair Value, Recurring [Member]
Repayment of debt
Repayments of Debt
Payment period from distributors received from date of sale
Trade receivables, credit period
Accounts Receivable Credit Period
Accounts receivable credit period
Tax Period
Tax Period [Domain]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Other Assets, Noncurrent, Total
Other long-term assets
Other Assets, Noncurrent
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Geographical
Geographical [Domain]
Customer
Customer [Domain]
Customer C
Customer C [Member]
Customer C.
Exercisable as of December 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Prior year—increases
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Treasury stock; 7,486,767 shares at December 31, 2021; 5,886,919 shares at December 31, 2020
Treasury Stock, Value, Ending Balance
Treasury Stock, Value, Beginning Balance
Treasury Stock, Value, Total
Treasury Stock, Value
Proceeds from issuance of common stock, net of transaction costs
Proceeds from Issuance of Common Stock