101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Condensed Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Condensed Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Condensed Consolidated Statements of Operations link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Condensed Consolidated Statement of Changes In Deficit link:calculationLink link:presentationLink link:definitionLink 107 - Statement - Condensed Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - Nature of Business and Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Intangible Assets link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Inventory link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Warrants and Warrant Derivative Liability link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Debt link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Equity link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Restructuring link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Co-Promotion Agreement link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - Intangible Assets (Tables) link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Inventory (Tables) link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Warrants and Warrant Derivative Liability (Tables) link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Restructuring (Tables) link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Nature of Business and Basis of Presentation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Summarizes Activity of the Product Revenue Allowance and Reserve Categories (Detail) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Product Revenue Recognized and Deferred (Detail) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Capitalized and Expensed (Detail) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Estimated Useful Lives (Detail) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Net Income (or Loss) and Number of Shares Used to Compute Basic and Diluted Earnings per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Anti-Dilutive Securities Not Included in Computation of Net Income (or Loss) per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Assets and Liability Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Carrying Amounts and Estimated Fair Values of Debt Instruments (Detail) link:calculationLink link:presentationLink link:definitionLink 135 - 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Disclosure - Equity - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Restructuring - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Restructuring Charges Included in Accrued Expenses in Accompanying Consolidated Balance Sheets (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Co-Promotion Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink