Entity Central Index Key Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Information [Table] Document Information [Table] Class of Stock Statement Class Of Stock [Axis] Class of Stock Class Of Stock [Domain] American depositary share. American Depositary Shares American Depositary Share [Member] Ordinary shares. Ordinary Shares Ordinary Shares [Member] Document Information [Line Items] Document Information [Line Items] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Filer Category Entity Filer Category Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current Assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Restricted cash Restricted Cash And Cash Equivalents At Carrying Value Accounts receivable, net Accounts Receivable Net Current Inventory, net Inventory Net Prepaid and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Property, plant and equipment, net Property Plant And Equipment Net Other long-term assets Other Assets Noncurrent Intangible asset, net Finite Lived Intangible Assets Net TOTAL ASSETS Assets LIABILITIES AND STOCKHOLDERS’ DEFICIT Liabilities And Stockholders Equity [Abstract] Current Liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses and other current liabilities Accrued Liabilities And Other Liabilities Current portion of exchangeable senior notes, net of discount Senior Notes Current Current portion of long-term debt from royalty-bearing instrument Long Term Debt Current Deferred revenue, current Deferred Revenue Current Total current liabilities Liabilities Current Long-Term Liabilities: Liabilities Noncurrent [Abstract] Exchangeable senior notes, net of discount Senior Long Term Notes Long-term debt from royalty-bearing instrument Long Term Debt Noncurrent Deferred revenue, long-term Deferred Revenue Noncurrent Other long-term liabilities Other Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 6) Commitments And Contingencies Stockholders’ Deficit: Stockholders Equity [Abstract] Series A Convertible Preferred Stock, £0.05 par, unlimited authorized; 328,184,640 shares issued and outstanding as of March 31, 2018 and December 31, 2017 (equivalent to 32,818,464 ordinary shares upon future consolidation and redesignation at a 10:1 ratio) Preferred Stock Value Common stock, £0.50 par, unlimited authorized; 295,956,415 issued, 293,584,140 outstanding as of March 31, 2018; 272,719,044 issued, 271,022,011 outstanding as of December 31, 2016 Common Stock Value Additional paid-in capital Additional Paid In Capital Treasury stock; 2,372,275 shares as of March 31, 2018; 1,697,033 shares as of December 31, 2017 Treasury Stock Value Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ deficit Stockholders Equity TOTAL LIABILITIES AND STOCKHOLDERS’ DEFICIT Liabilities And Stockholders Equity Preferred stock, equivalent ordinary shares upon future conversion outstanding. Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized, unlimited Preferred Stock Shares Authorized Unlimited Preferred stock, issued Preferred Stock Shares Issued Preferred stock, shares outstanding Preferred Stock Shares Outstanding Preferred stock, equivalent ordinary shares upon future consolidation outstanding Preferred Stock Equivalent Ordinary Shares Upon Future Conversion Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized, unlimited Common Stock Shares Authorized Unlimited Common stock, issued Common Stock Shares Issued Common stock, outstanding Common Stock Shares Outstanding Treasury stock, shares Treasury Stock Shares Income Statement [Abstract] Product revenue, net Sales Revenue Goods Net Licensing revenue Licenses Revenue Total revenue, net Revenues Less: Cost of goods sold Cost Of Goods Sold Gross margin Gross Profit Operating expenses: Operating Expenses [Abstract] Selling, general and administrative Selling General And Administrative Expense Research and development Research And Development Expense Total operating expenses Operating Expenses Operating loss Operating Income Loss Interest expense, net Interest Income Expense Nonoperating Net Other income (expense), net Other Nonoperating Income Expense Loss from operations before taxes Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest (Provision for) benefit from income taxes Income Tax Expense Benefit Net loss Net Income Loss Loss per share: Earnings Per Share Basic And Diluted [Abstract] Basic Earnings Per Share Basic Diluted Earnings Per Share Diluted Weighted average shares: Weighted Average Number Of Shares Outstanding [Abstract] Basic Weighted Average Number Of Shares Outstanding Basic Diluted Weighted Average Number Of Diluted Shares Outstanding Shares Outstanding, Adjusted Balance Stockholders equity adjusted balance. Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Preferred Shares Preferred Stock [Member] Common Shares Common Stock [Member] Treasury Stock Treasury Stock [Member] Additional Paid-in Capital Additional Paid In Capital [Member] Accumulated Deficit Retained Earnings [Member] Adjustments for New Accounting Pronouncements Adjustments For New Accounting Pronouncements [Axis] Type of Adoption Type Of Adoption [Member] Accounting Standards Update 2014-09 Accounting Standards Update201409 [Member] Statement [Line Items] Statement [Line Items] Balance Balance (in shares) Shares Outstanding Balance (Cumulative-effect adjustment) Cumulative Effect On Retained Earnings Net Of Tax1 Balance Stockholders Equity Adjusted Balance Balance (in shares) Shares Outstanding Adjusted Balance Issuance of common stock, net of transaction costs Stock Issued During Period Value New Issues Issuance of common stock, net of transaction costs (shares) Stock Issued During Period Shares New Issues Exercise of stock options Stock Issued During Period Value Stock Options Exercised Exercise of stock options (in shares) Stock Issued During Period Shares Stock Options Exercised Vesting of restricted stock units Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures Vesting of restricted stock units (in shares) Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures Stock-based compensation Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Loss for the period Balance Balance (in shares) Proceeds from issuance of exchangeable debt. Cash Paid During Period For [Abstract] Statement Of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided By Used In Operating Activities [Abstract] Net loss Adjustments to reconcile loss to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation and amortization Depreciation And Amortization Stock-based compensation Share Based Compensation Amortization of debt discount and debt issuance costs Amortization Of Financing Costs And Discounts Amortization of intangible asset Amortization Of Intangible Assets Changes in assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable, net Increase Decrease In Accounts Receivable Inventory, net Increase Decrease In Inventories Prepaid and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other long-term assets Increase Decrease In Other Noncurrent Assets Accrued interest payable Increase Decrease In Interest Payable Net Deferred revenue Increase Decrease In Deferred Revenue Accounts payable and other current liabilities Increase Decrease In Accounts Payable And Other Operating Liabilities Other long-term liabilities Increase Decrease In Other Noncurrent Liabilities Net cash used in operating activities Net Cash Provided By Used In Operating Activities Continuing Operations CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided By Used In Investing Activities [Abstract] Purchases of equipment Payments To Acquire Property Plant And Equipment Net cash used in investing activities Net Cash Provided By Used In Investing Activities Continuing Operations CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from issuance of exchangeable debt Proceeds From Issuance Of Exchangeable Debt Payment of debt issuance costs Payments Of Debt Issuance Costs Proceeds from issuance of common stock, net of transaction costs Proceeds From Issuance Of Common Stock Proceeds from exercise of stock options, net of transaction costs Proceeds From Stock Options Exercised Repurchase of exchangeable senior notes Repayments Of Convertible Debt Payment on long-term debt from royalty-bearing instrument Repayments Of Long Term Debt Taxes paid related to stock-based awards Payments Related To Tax Withholding For Share Based Compensation Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Continuing Operations NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD Supplemental disclosure of cash flow information: Supplemental Cash Flow Information [Abstract] Cash paid during the year for: Cash Paid During Period For [Abstract] Interest Interest Paid Income taxes Income Taxes Paid Accounting Policies [Abstract] Nature of Business and Basis of Presentation Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block] Significant Accounting Policies Significant Accounting Policies [Text Block] Goodwill And Intangible Assets Disclosure [Abstract] Intangible Assets Intangible Assets Disclosure [Text Block] Inventory Disclosure [Abstract] Inventory Inventory Disclosure [Text Block] Debt Disclosure [Abstract] Debt Debt Disclosure [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Equity [Abstract] Equity Stockholders Equity Note Disclosure [Text Block] Co promotion agreement disclosure. Co-promotion agreement. Co Promotion Agreement [Abstract] Co-Promotion Agreement Co Promotion Agreement Disclosure [Text Block] Revenue From Contract With Customer [Abstract] Revenue Recognition Revenue From Contract With Customer [Text Block] Organization Consolidation And Presentation Of Financial Statements [Abstract] Development, Commercialization and Supply Agreements Collaborative Arrangement Disclosure [Text Block] Subsequent Events [Abstract] Subsequent Events Subsequent Events [Text Block] Principles of Consolidation Consolidation Policy [Text Block] Use of Estimates Use Of Estimates Use of forecasted financial information in accounting estimates. Use of Forecasted Financial Information in Accounting Estimates Use Of Forecasted Financial Information In Accounting Estimates Policy [Text Block] Revenue Recognition Revenue Recognition Policy [Text Block] Distribution Costs Shipping And Handling Cost Policy [Text Block] Cash and Cash Equivalents and Restricted Cash Cash And Cash Equivalents Policy [Text Block] Accounts Receivable, net Receivables Policy [Text Block] Inventory Inventory Policy [Text Block] Property, Plant and Equipment Property Plant And Equipment Policy [Text Block] Long-Lived Asset Impairment Impairment Or Disposal Of Long Lived Assets Policy [Text Block] Intangible Asset, net Intangible Assets Finite Lived Policy Costs for Patent Litigation and Legal Proceedings Legal Costs Policy [Text Block] Research and Development Costs Research And Development Expense Policy Selling, General and Administrative Costs Selling General And Administrative Expenses Policy [Text Block] Income Taxes Income Tax Policy [Text Block] Loss per Share Earnings Per Share Policy [Text Block] Debt Instruments Debt Policy [Text Block] Stock-Based Compensation Share Based Compensation Option And Incentive Plans Policy Concentration of Credit Risk Concentration Risk Credit Risk Concentration of suppliers. Concentration of Suppliers Concentration Of Suppliers Policy [Text Block] Foreign Currency Foreign Currency Transactions And Translations Policy [Text Block] Fair Value of Financial Instruments Fair Value Of Financial Instruments Policy Derivative Liabilities Derivatives Policy [Text Block] Segment and Geographical Information Segment Reporting Policy Policy [Text Block] Recent Accounting Pronouncements New Accounting Pronouncements Policy Policy [Text Block] Summarizes the Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable Schedule Of Accounts Notes Loans And Financing Receivable [Text Block] Property, plant and equipment, useful life. Estimated Useful Lives Property Plant And Equipment Useful Life Table [Text Block] Net Loss and the Number of Shares Used to Compute Basic and Diluted Net Loss per Share Schedule Of Earnings Per Share Basic And Diluted Table [Text Block] Anti-Dilutive Securities Not Included in the Computation of Net Loss or Earnings per Share Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Assets and Liability Measured at Fair Value on a Recurring Basis Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block] Carrying Amounts and Estimated Fair Values of Debt Instruments Schedule Of Carrying Values And Estimated Fair Values Of Debt Instruments Table [Text Block] Schedule of Carrying Value of Intangible Asset Schedule Of Finite Lived Intangible Assets Table [Text Block] Schedule of Inventory Schedule Of Inventory Current Table [Text Block] Summary of net product revenue valuation allowances. Summarize Activity of the Net Product Revenue Allowance and Reserve Categories Summary Of Net Product Revenue Valuation Allowances Table [Text Block] Changes in Balances of Contract Assets and Liabilities and Revenues Recognized Contract With Customer Asset And Liability Table [Text Block] Number of patients enrolled and randomized in study. Organization, consolidation and presentation of financial statements disclosure. Organization, consolidation and presentation of financial statements disclosure. Organization Consolidation And Presentation Of Financial Statements Disclosure [Table] Organization Consolidation And Presentation Of Financial Statements Disclosure [Table] Long-term Debt, Type Longterm Debt Type [Axis] Long-term Debt, Type Longterm Debt Type [Domain] Convertible Debt Convertible Debt [Member] Debt Instrument Debt Instrument [Axis] Debt Instrument, Name Debt Instrument Name [Domain] Senior notes four. 2017 Notes Senior Notes Four [Member] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] REDUCE-IT study, number of patients enrolled and randomized Number Of Patients Enrolled And Randomized In Study Number of sales professionals. Number of sales professionals Number Of Sales Professionals Number of operating segments Number Of Operating Segments Debt instrument maturity date year. Total current assets Convertible senior notes, principal amount Debt Instrument Face Amount Convertible senior notes, due date Debt Instrument Maturity Date Year Convertible senior notes, stated interest rate Debt Instrument Interest Rate Stated Percentage Convertible senior notes, repurchase price at option of the issuer Debt Instrument Redemption Price Percentage Accounts receivable credit period Significant accounting policies. Significant Accounting Policies [Table] Significant Accounting Policies [Table] Significant Accounting Policies [Table] Customer Major Customers [Axis] Customer Name Of Major Customer [Domain] Customer A. Customer A Customer A [Member] Customer B. Customer B Customer B [Member] Customer C. Customer C Customer C [Member] Concentration Risk Benchmark Concentration Risk By Benchmark [Axis] Concentration Risk Benchmark Concentration Risk Benchmark [Domain] Gross Product Sales Sales Revenue Net [Member] Accounts Receivable Accounts Receivable [Member] Concentration Risk Type Concentration Risk By Type [Axis] Concentration Risk Type Concentration Risk Type [Domain] Customer Concentration Risk Customer Concentration Risk [Member] Derivative Instrument Derivative Instrument Risk [Axis] Derivative Contract Derivative Contract Type [Domain] Embedded Derivative Financial Instruments Embedded Derivative Financial Instruments [Member] Segments Statement Business Segments [Axis] Segments Segment [Domain] Biopharmaceutical. BioPharma Debt Biopharmaceutical [Member] Range Range [Axis] Range Range [Member] Minimum Minimum [Member] Maximum Maximum [Member] Initial Application Period Cumulative Effect Transition Initial Application Period Cumulative Effect Transition [Axis] Initial Application Period Cumulative Effect Transition Initial Application Period Cumulative Effect Transition [Domain] Difference between Revenue Guidance in Effect before and after Topic 606 Difference Between Revenue Guidance In Effect Before And After Topic606 [Member] Significant Accounting Policies [Line Items] Significant Accounting Policies [Line Items] Trade receivables, credit period Accounts Receivable Credit Period Schedule Of Accounts Notes Loans And Financing Receivable [Table] Schedule Of Accounts Notes Loans And Financing Receivable [Table] Valuation Allowances and Reserves Type Valuation Allowances And Reserves Type [Axis] Valuation Allowances and Reserves Valuation Allowances And Reserves [Domain] Trade Allowances Allowance For Trade Receivables [Member] Allowance for Estimated Chargebacks [Member] Chargebacks Allowance For Estimated Chargebacks [Member] Accounts, Notes, Loans and Financing Receivable [Line Items] Accounts Notes And Loans Receivable [Line Items] Gross trade accounts receivable Accounts Receivable Gross Current Valuation allowances and reserves Valuation Allowances And Reserves Balance Accounts receivable, net Property Plant And Equipment [Abstract] Schedule Of Property Plant And Equipment [Table] Schedule Of Property Plant And Equipment [Table] Property, Plant and Equipment, Type Property Plant And Equipment By Type [Axis] Property, Plant and Equipment, Type Property Plant And Equipment Type [Domain] Computer equipment and capitalized software. Computer equipment and software Computer Equipment And Capitalized Software [Member] Furniture and Fixtures Furniture And Fixtures [Member] Leasehold improvements Leasehold Improvements [Member] Property, Plant and Equipment [Line Items] Property Plant And Equipment [Line Items] Property Plant and Equipment Useful Life Property Plant And Equipment Useful Life Property Plant and Equipment Useful Life Property Plant And Equipment Estimated Useful Lives U.S. federal corporate tax rate Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate Net income loss available to common stockholders basic and diluted. Earnings Per Share [Abstract] Net loss—basic and diluted Net Income Loss Available To Common Stockholders Basic And Diluted Weighted average shares outstanding—basic and diluted Weighted Average Number Of Share Outstanding Basic And Diluted Net loss per share—basic and diluted Earnings Per Share Basic And Diluted Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Antidilutive Securities Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities, Name Antidilutive Securities Name [Domain] Stock Options Stock Compensation Plan [Member] Restricted Stock Units (RSUs) Restricted Stock Units R S U [Member] Exchangeable Senior Notes Convertible Debt Securities [Member] Major Types of Debt and Equity Securities Major Types Of Debt And Equity Securities [Axis] Major Types of Debt and Equity Securities Major Types Of Debt And Equity Securities [Domain] Preferred Stock Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Anti-dilutive securities Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Aggregate principal amount of notes Senior Notes Convertible senior notes, discount Debt Instrument Unamortized Discount Concentration risk percentage Concentration Risk Percentage1 Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Measurement Frequency Fair Value By Measurement Frequency [Axis] Fair Value, Measurement Frequency Fair Value Measurement Frequency [Domain] Fair Value, Measurements, Recurring Fair Value Measurements Recurring [Member] Fair Value, Hierarchy Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Hierarchy Fair Value Measurements Fair Value Hierarchy [Domain] Level 1 Fair Value Inputs Level1 [Member] Level 2 Fair Value Inputs Level2 [Member] Level 3 Fair Value Inputs Level3 [Member] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Asset: Assets Fair Value Disclosure [Abstract] Cash equivalents—money markets Cash And Cash Equivalents Fair Value Disclosure Long term debt current net of accrued interest. Debt Instrument [Table] Debt Instrument [Table] Senior notes six. 2017 Notes Senior Notes Six [Member] Measurement Basis Fair Value By Measurement Basis [Axis] Fair Value Disclosure Item Amounts [Default] Portion At Fair Value Fair Value Disclosure [Member] Fair Value Measurement Fair Value Disclosure Item Amounts [Domain] Long-term debt from royalty-bearing instrument Estimate Of Fair Value Fair Value Disclosure [Member] Debt Instrument [Line Items] Debt Instrument [Line Items] Current portion of long-term debt from royalty-bearing instrument, net of accrued interest, carrying value Long Term Debt Current Net Of Accrued Interest Long-term debt from royalty-bearing instrument, carrying value Total long-term debt from royalty-bearing instrument, carrying value Long Term Debt Exchangeable senior notes, carrying value Long term debt fair value current net of accrued interest. Long term debt fair value non current. Current portion of long-term debt from royalty-bearing instrument, net of accrued interest, estimated fair value Long Term Debt Fair Value Current Net Of Accrued Interest Long-term debt from royalty-bearing instrument, estimated fair value Long Term Debt Fair Value Noncurrent Total long-term debt from royalty-bearing instrument, estimated fair value Long Term Debt Fair Value Exchangeable senior notes, estimated fair value Debt Instrument Fair Value Fair value assumptions coupon rate. Fair value assumptions, comparable yield to maturity. Maximum repayment of future revenue and receivables Other Commitment Derivative liability fair value assumptions, term Fair Value Assumptions Expected Term Derivative liability fair value assumption, coupon rate Fair Value Assumptions Coupon Rate Derivative liability fair value assumptions, market yields Fair Value Assumptions Comparable Yield To Maturity Fair value of embedded derivative liability Embedded Derivative Fair Value Of Embedded Derivative Liability Gain (loss) on change in fair value of derivative liabilities Unrealized Gain Loss On Derivatives Intangible asset estimated weighted- average remaining useful life Finite Lived Intangible Assets Remaining Amortization Period1 Technology rights Finite Lived Intangible Assets Gross Accumulated amortization Finite Lived Intangible Assets Accumulated Amortization Intangible assets, net Raw materials Inventory Raw Materials Work in process Inventory Work In Process Finished goods Inventory Finished Goods Inventory Inventory Gross Inventory reserve Inventory Valuation Reserves Inventory, net Debt disclosure. Debt disclosure. Debt Disclosure [Table] Debt Disclosure [Table] Related Party Related Party Transactions By Related Party [Axis] Related Party Related Party [Domain] CPPIB. CPPIB C P P I B [Member] Royalty-bearing debt. Royalty-Bearing Debt Royalty Bearing Debt [Member] Scenario Statement Scenario [Axis] Scenario, Unspecified Scenario Unspecified [Domain] Charges cash. Cash Charges Cash [Member] Non-cash. Non Cash Non Cash [Member] Debt Disclosure [Line Items] Debt Disclosure [Line Items] Amount received at the closing of the agreement Proceeds From Issuance Of Long Term Debt Guarantee payments. Future Minimum Guarantee Payments Repayment under agreement Guarantee Payments Future minimum repayment under agreement Future Minimum Guarantee Payments Long-term debt from royalty-bearing instrument, carrying amount net of unamortized discount Interest expense, contractual coupon interest Interest Expense Debt Excluding Amortization Interest expense, non-cash Debt instrument aggregate principal amount redeemed. Senior notes one. 2012 Notes Senior Notes One [Member] 2012, 2014 and 2015 notes. 2012, 2014 and 2015 Notes Two Thousand Twelve Two Thousand Fourteen And Two Thousand Fifteen Notes [Member] Convertible senior notes, principal amount purchase Debt Instrument Repurchased Face Amount Convertible senior notes, aggregate principal amount redeemed Debt Instrument Aggregate Principal Amount Redeemed Convertible senior notes, outstanding amount Convertible Debt Current Net proceeds from offering Proceeds From Debt Net Of Issuance Costs Convertible senior notes, interest payable dates Debt Instrument Frequency Of Periodic Payment Convertible senior notes, payment start date Debt Instrument Date Of First Required Payment1 Convertible senior notes, maturity date Debt Instrument Maturity Date Debt instrument, convertible, premium on conversion price, percentage. Excess principal value over fair value. Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes Debt Instrument Convertible Conversion Ratio1 Convertible senior notes, initial exchange price Debt Instrument Convertible Conversion Price1 Convertible senior notes, percentage of premium initial exchange price Debt Instrument Convertible Premium On Conversion Price Percentage Convertible senior notes, total ADS into which the debt is exchangeable Debt Instrument Convertible Number Of Equity Instruments Value of shares in excess of principal value of Notes based on closing price Excess Principal Value Over Fair Value Convertible senior notes, redemption start date Debt Instrument Redemption Period Start Date Convertible senior notes redemption, end date Debt Instrument Redemption Period End Date Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price Debt Instrument Convertible Threshold Percentage Of Stock Price Trigger Convertible senior notes, mandatory exchange in whole or in part if daily VWAP, stock trigger price Debt Instrument Convertible Stock Price Trigger Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days Debt Instrument Convertible Threshold Consecutive Trading Days1 Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days Debt Instrument Convertible Threshold Trading Days Debt instrument, debt default, threshold percentage of principal amount to issue notice. Percentage of holders of principal amount required to issue notice on default Debt Instrument Debt Default Threshold Percentage Of Principal Amount To Issue Notice Convertible notes, carrying amount net of unamortized discount Convertible Debt Convertible notes, interest expense Interest Expense Debt Accrued interest on convertible note Interest Payable Current Royalty, milestone or minimum purchase commitments. Commitments and contingencies disclosure. Commitments and contingencies disclosure. Commitments And Contingencies Disclosure [Table] Commitments And Contingencies Disclosure [Table] Nisshin Pharma, Inc. Nisshin Nisshin Pharma Inc [Member] Further indication for AMR101. Further Indication for AMR101 Further Indication For A M R One Zero One [Member] Business Developments [Axis] Business Developments Business Developments [Axis] Business Development [Domain] Business Development Business Development [Domain] Marketing approval in Europe. Marketing Approval In Europe Marketing Approval In Europe [Member] Potential marketing approval 1. Potential Marketing Approval 1 Potential Marketing Approval One [Member] Potential marketing approval 2. Potential Marketing Approval 2 Potential Marketing Approval Two [Member] Commitments And Contingencies Disclosure [Line Items] Commitments And Contingencies Disclosure [Line Items] Royalty, milestone or minimum purchase commitments Royalty Milestone Or Minimum Purchase Commitments Potential aggregate stock or cash payment Royalty Guarantees Commitments Amount Private Placement Closing Date Stockholders Equity Note [Line Items] Stockholders Equity Note [Table] Stockholders Equity Note [Table] Stockholders Equity Note [Table] Series A Preferred Stock Series A Preferred Stock [Member] Preferred shares basis. Preferred Shares Basis Preferred Shares Basis [Member] Ordinary shares basis. Ordinary Shares Basis Ordinary Shares Basis [Member] Sale of Stock Subsidiary Sale Of Stock [Axis] Sale of Stock Sale Of Stock Name Of Transaction [Domain] Second private placement. Second Private Placement Second Private Placement [Member] Preferred stock purchase option. Preferred Stock Purchase Option Preferred Stock Purchase Option [Member] Stockholders Equity Note [Line Items] Stockholders Equity Note [Line Items] Issuance of stock (shares) American depositary shares conversion rate to preference shares Preferred Stock Conversion Basis Private placement, closing date Private Placement Closing Date Stock issued under private placement, value Equity offering costs. Conversion price per share. Share conversion price Conversion Price Per Share Aggregate gross proceeds Proceeds From Issuance Of Private Placement Estimated offering expense Equity Offering Costs Beneficial ownership limitation percentage. Beneficial ownership limitation Beneficial Ownership Limitation Percentage Number of shares issued for each preference shares Convertible Preferred Stock Shares Issued Upon Conversion Convertible senior notes, total ADS into which the debt is exchangeable Stock Issued During Period Shares Conversion Of Convertible Securities Market value, per share Share Price BCF resulting from issuance of Series A Preference Shares Preferred Stock Conversions Inducements Derivative liabilities transferred to stockholders equity. Derivative liability at fair value Derivative Fair Value Of Derivative Liability Gain (loss) on change in fair value of derivatives Derivative Gain Loss On Derivative Net Transfer derivative liability to equity Derivative Liabilities Transferred To Stockholders Equity Public offering over allotment option exercise period. Stock issued during period shares new issues exercised. Over-Allotment Option Over Allotment Option [Member] Over allotment option, exercisable period Public Offering Over Allotment Option Exercise Period Issuance of stock (shares), exercised Stock Issued During Period Shares New Issues Exercised Sale of stock price per share Sale Of Stock Price Per Share Net proceeds from public offering Percentage of outstanding common shares and preferred shares on fully diluted basis. Award Type Award Type [Axis] Equity Award Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Stock Options Employee Stock Option [Member] Plan Name Plan Name [Axis] Plan Name Plan Name [Domain] Stock Incentive Plan 2011. Stock Incentive Plan 2011 Stock Incentive Plan Twenty Eleven [Member] Vesting Vesting [Axis] Vesting Vesting [Domain] Vesting period. Vesting Period Vesting Period [Member] Vesting period five. Vest over a three year period Vesting Period Five [Member] Stock options, outstanding Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Restricted stock units, outstanding Share Based Compensation Arrangement By Share Based Payment Award Non Option Equity Instruments Outstanding Number Percentage of outstanding shares on a fully diluted basis Percentage Of Outstanding Common Shares And Preferred Shares On Fully Diluted Basis Shares issued, exercise of stock options Stock units, Granted Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Stock options, Granted Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Stock units, Vesting Period Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1 Share based compensation arrangement by share based payment award equity instruments other than options settlement. Settlement of shares, related to the vesting of RSUs Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Settlement Shares issued, related to the vesting of RSUs Stock Issued During Period Shares Share Based Compensation Treasury shares for settlement of employee tax obligations Shares Paid For Tax Withholding For Share Based Compensation Agreement amended date. Related Party Transactions [Abstract] Co-promotion agreement. Co-promotion agreement. Co Promotion Agreement [Table] Co Promotion Agreement [Table] Type of Arrangement and Non-arrangement Transactions Type Of Arrangement [Axis] Arrangements and Non-arrangement Transactions Arrangements And Nonarrangement Transactions [Member] Co promotion agreement. Co-Promotion Agreement (the Agreement) Co Promotion Agreement [Member] Counterparty Name Counterparty Name [Axis] Counterparty Name Repurchase Agreement Counterparty Name [Domain] Kowa pharmaceuticals America. Kowa Pharmaceuticals America Kowa Pharmaceuticals America [Member] Co Promotion Agreement [Line Items] Co Promotion Agreement [Line Items] Agreement amended date Agreement Amended Date Percentage of gross margin, payable for promotion agreement. Range of percentage of gross margin payable for co-promotion agreement. Maximum co-promotion tail payments receive period. Accrued co promotion tail payments. Promotion fee as a percentage of gross margin Percentage Of Gross Margin Payable For Promotion Agreement Promotion fee as a percentage gross margin Range Of Percentage Of Gross Margin Payable For Co Promotion Agreement Maximum co-promotion tail payments receive period Maximum Co Promotion Tail Payments Receive Period Accrued co- promotion tail payments Accrued Co Promotion Tail Payments Disaggregation Of Revenue [Table] Disaggregation Of Revenue [Table] Products and Services Product Or Service [Axis] Products and Services Products And Services [Domain] Vascepa 1-gram. Vascepa 1-Gram Vascepa One Gram [Member] Vascepa 0.5-gram. Vascepa 0.5-Gram Vascepa Half Gram [Member] Disaggregation Of Revenue [Line Items] Disaggregation Of Revenue [Line Items] Payment period from distributors received from date of sale Cash discount percent. Sales discount percentage Cash Discount Percent Product expiration period upon conversion into capsule form. Product expiration date after being converted into capsule form Product Expiration Period Upon Conversion Into Capsule Form Provision related to prior period sales. Credits/payments made for prior period sales. Valuation And Qualifying Accounts Disclosure [Table] Valuation And Qualifying Accounts Disclosure [Table] Rebates chargebacks and discounts. Rebates, Chargebacks and Discounts Rebates Chargebacks And Discounts [Member] Product Returns Allowance For Sales Returns [Member] Other incentive programs. Other Incentives Other Incentive Programs [Member] Valuation and Qualifying Accounts Disclosure [Line Items] Valuation And Qualifying Accounts Disclosure [Line Items] Beginning balance Provision related to current period sales Valuation Allowances And Reserves Charged To Cost And Expense Provision related to prior period sales Provision Related To Prior Period Sales Credits/payments made for current period sales Valuation Allowances And Reserves Deductions Credits/payments made for prior period sales Credits Payments Made For Prior Period Sales Ending balance Effect of significant financing component when transfer and customer payment of good or service occurs within one year or less Revenue Practical Expedient Financing Component Non refundable upfront payments received. Nonrefundable milestone payment. License And Collaboration Agreements [Line Items] License And Collaboration Agreements [Table] License And Collaboration Agreements [Table] License And Collaboration Agreements [Table] Eddingpharm [Member] Eddingpharm Eddingpharm [Member] Deferred Revenue Arrangement Type Deferred Revenue Arrangement Type [Axis] Deferred Revenue Deferred Revenue Arrangement Type [Domain] Clinical trial application. Clinical Trial Application Clinical Trial Application [Member] Biologix [Member] Biologix FZCo Biologix [Member] HLS Therapeutics Incorporation. HLS H L S Therapeutics Incorporation [Member] License And Collaboration Agreements [Line Items] License And Collaboration Agreements [Line Items] Non-refundable up-front received Non Refundable Upfront Payments Received Non-refundable milestone payment Nonrefundable Milestone Payment Eligible milestone payment. Number of regulatory milestone events indications. Eligible regulatory milestone event payment. Eligible sales based milestone event payment. Additional upfront payment eligible to receive based on development, regulatory and sales Milestone Eligible Milestone Payment Number of indications of the regulatory milestone events relating to the submission and approval Number Of Regulatory Milestone Events Indications Amounts to be received upon achievement of the regulatory milestone events Eligible Regulatory Milestone Event Payment Sales-based milestone event payment Eligible Sales Based Milestone Event Payment Licenses revenue to date. Licenses revenue to date Licenses Revenue To Date Deferred revenue Deferred Revenue Revenue recognized over remaining period Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Period Estimated number of days following the end of the quarter before related revenue is recognized. Revenue recognition period of non-refundable up-front payment Deferred Revenue Recognition Period Non refundable upfront payments received period. Non-refundable up-front received period Non Refundable Upfront Payments Received Period Contract with customer assets additions. Contract with Customer asset deductions. Contract With Customer Asset And Liability [Abstract] Contract assets, Balance at Beginning of Period Contract With Customer Asset Net Contract assets, Additions Contract With Customer Assets Additions Contract assets, Deductions Contract With Customer Asset Deductions Contract assets, Balance at End of Period Contract liabilities: Contract With Customer Liability [Abstract] Deferred revenue, Balance at Beginning of Period Deferred revenue, Additions Deferred Revenue Additions Deferred revenue, Deductions Contract With Customer Liability Revenue Recognized Deferred revenue, Balance at End of Period Change In Contract With Customer Asset And Liability [Abstract] Revenue recognized in the period from: Change In Contract With Customer Liability [Abstract] Amounts included in contract liability at the beginning of the period Performance obligations satisfied in previous periods Contract With Customer Performance Obligation Satisfied In Previous Period