Entity Central Index Key Income Tax Reconciliation, Derivative Liabilities Income tax reconciliation windfall tax benefit. Tax cuts and jobs act of 2017 change in tax rate reconciliation change in tax reform. Income Tax Rate Reconciliation, Cumulative Translation Adjustment, Amount Income tax reconciliation tax reserve. Income tax reconciliation long term debt royalty bearing instrument. Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Information [Table] Document Information [Table] Class of Stock Statement Class Of Stock [Axis] Class of Stock Class Of Stock [Domain] American depositary share. American Depositary Shares American Depositary Share [Member] Ordinary shares. Ordinary Shares Ordinary Shares [Member] Document Information [Line Items] Document Information [Line Items] Document Type Document Type Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Entity Registrant Name Entity Registrant Name Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Emerging Growth Company Entity Emerging Growth Company Entity Shell Company Entity Shell Company Entity Small Business Entity Small Business Entity Public Float Entity Public Float Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Accrued liabilities and other liabilities current. Statement Of Financial Position [Abstract] ASSETS Assets [Abstract] Current Assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Restricted cash Restricted Cash And Cash Equivalents At Carrying Value Accounts receivable, net Accounts Receivable Net Current Inventory Inventory Net Prepaid and other current assets Prepaid Expense And Other Assets Current Total current assets Assets Current Property, plant and equipment, net Property Plant And Equipment Net Other long-term assets Other Assets Noncurrent Intangible asset, net Finite Lived Intangible Assets Net TOTAL ASSETS Assets LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT) Liabilities And Stockholders Equity [Abstract] Current Liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued expenses and other current liabilities Accrued Liabilities And Other Liabilities Current Current portion of exchangeable senior notes, net of discount Senior Notes Current Current portion of long-term debt from royalty-bearing instrument Long Term Debt Current Deferred revenue, current Contract With Customer Liability Current Total current liabilities Liabilities Current Long-Term Liabilities: Liabilities Noncurrent [Abstract] Exchangeable senior notes, net of discount Senior Long Term Notes Long-term debt from royalty-bearing instrument Long Term Debt Noncurrent Deferred revenue, long-term Contract With Customer Liability Noncurrent Other long-term liabilities Other Liabilities Noncurrent Total liabilities Liabilities Commitments and contingencies (Note 8) Commitments And Contingencies Stockholders’ Equity (Deficit): Stockholders Equity [Abstract] Series A Convertible Preferred Stock, £0.05 par, unlimited authorized; 289,317,460 shares issued and outstanding as of December 31, 2018 (equivalent to 28,931,746 ordinary shares upon future consolidation and redesignation at a 10:1 ratio); 328,184,640 shares issued and outstanding as of December 31, 2017 (equivalent to 32,818,464 ordinary shares upon future consolidation and redesignation at a 10:1 ratio) Preferred Stock Value Common stock, £0.50 par, unlimited authorized; 329,110,863 issued, 325,850,013 outstanding as of December 31, 2018; 272,719,044 issued, 271,022,011 outstanding as of December 31, 2017 Common Stock Value Additional paid-in capital Additional Paid In Capital Treasury stock; 3,260,850 shares as of December 31, 2018; 1,697,033 shares as of December 31, 2017 Treasury Stock Value Accumulated deficit Retained Earnings Accumulated Deficit Total stockholders’ equity (deficit) Stockholders Equity TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT) Liabilities And Stockholders Equity Preferred stock, equivalent ordinary shares upon future conversion outstanding. Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized, unlimited Preferred Stock Shares Authorized Unlimited Preferred stock, issued Preferred Stock Shares Issued Preferred stock, shares outstanding Preferred Stock Shares Outstanding Preferred stock, equivalent ordinary shares upon future consolidation outstanding Preferred Stock Equivalent Ordinary Shares Upon Future Conversion Outstanding Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized, unlimited Common Stock Shares Authorized Unlimited Common stock, issued Common Stock Shares Issued Common stock, outstanding Common Stock Shares Outstanding Treasury stock, shares Treasury Stock Shares Income Statement [Abstract] Statement [Table] Statement [Table] Product and Service Product Or Service [Axis] Product and Service Products And Services [Domain] Product Revenue, Net Product [Member] Licensing Revenue License [Member] Statement [Line Items] Statement [Line Items] Total revenue, net Revenue From Contract With Customer Excluding Assessed Tax Less: Cost of goods sold Cost Of Goods And Services Sold Gross margin Gross Profit Operating expenses: Operating Expenses [Abstract] Selling, general and administrative Selling General And Administrative Expense Research and development Research And Development Expense Total operating expenses Operating Expenses Operating loss Operating Income Loss Gain on change in fair value of derivative liabilities Unrealized Gain Loss On Derivatives Interest expense Interest Expense Interest income Investment Income Interest Other (expense) income, net Other Nonoperating Income Expense Loss from operations before taxes Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest Provision for income taxes Income Tax Expense Benefit Net loss Net Income Loss Loss per share: Earnings Per Share Basic And Diluted [Abstract] Basic Earnings Per Share Basic Diluted Earnings Per Share Diluted Weighted average shares outstanding: Weighted Average Number Of Shares Outstanding [Abstract] Basic Weighted Average Number Of Shares Outstanding Basic Diluted Weighted Average Number Of Diluted Shares Outstanding Shares Outstanding, Adjusted Balance Stockholders equity adjusted balance. Stock issued during period, shares, conversion of convertible securities, net of adjustments. Statement Of Stockholders Equity [Abstract] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Preferred Shares Preferred Stock [Member] Common Shares Common Stock [Member] Treasury Stock Treasury Stock [Member] Additional Paid-in Capital Additional Paid In Capital [Member] Accumulated Deficit Retained Earnings [Member] Adjustments for New Accounting Pronouncements Adjustments For New Accounting Pronouncements [Axis] Type of Adoption Type Of Adoption [Member] Accounting Standards Update 2014-09 Accounting Standards Update201409 [Member] Balance Balance (in shares) Shares Outstanding Balance (Cumulative-effect adjustment) Cumulative Effect On Retained Earnings Net Of Tax1 Issuance of common stock, net of transaction costs Stock Issued During Period Value New Issues Issuance of common stock, net of transaction costs (shares) Stock Issued During Period Shares New Issues Issuance of common stock under employee stock purchase plan Stock Issued During Period Value Employee Stock Purchase Plan Issuance of common stock under employee stock purchase plan (in shares) Stock Issued During Period Shares Employee Stock Purchase Plans Exchange of exchangeable senior notes, net of transaction costs Stock Issued During Period Value Conversion Of Convertible Securities Net Of Adjustments Exchange of exchangeable senior notes, net of transaction costs (in shares) Stock Issued During Period Shares Conversion Of Convertible Securities Net Of Adjustments Conversion of Series A Convertible Preferred Stock, net Stock Issued During Period Value Conversion Of Convertible Securities Conversion of Series A Convertible Preferred Stock, net (in shares) Stock Issued During Period Shares Conversion Of Convertible Securities Exercise of stock options Stock Issued During Period Value Stock Options Exercised Exercise of stock options (in shares) Stock Issued During Period Shares Stock Options Exercised Vesting of restricted stock units Stock Issued During Period Value Restricted Stock Award Net Of Forfeitures Vesting of restricted stock units (in shares) Stock Issued During Period Shares Restricted Stock Award Net Of Forfeitures Stock-based compensation Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Loss for the period Balance Stockholders Equity Adjusted Balance Balance (in shares) Shares Outstanding Adjusted Balance Balance Balance (in shares) Proceeds from issuance of exchangeable debt. Cash Paid During Period For [Abstract] Statement Of Cash Flows [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided By Used In Operating Activities [Abstract] Net loss Profit Loss Adjustments to reconcile loss to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation and amortization Depreciation And Amortization Loss on sale of fixed assets Gain Loss On Sale Of Property Plant Equipment Allowance for doubtful accounts Provision For Doubtful Accounts Stock-based compensation Share Based Compensation Amortization of debt discount and debt issuance costs Amortization Of Financing Costs And Discounts Amortization of intangible asset Amortization Of Intangible Assets Gain on change in fair value of derivative liabilities Deferred income taxes Deferred Income Tax Expense Benefit Changes in assets and liabilities: Increase Decrease In Operating Capital [Abstract] Accounts receivable, net Increase Decrease In Accounts Receivable Inventory Increase Decrease In Inventories Prepaid and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other long-term assets Increase Decrease In Other Noncurrent Assets Accrued interest payable Increase Decrease In Interest Payable Net Deferred revenue Increase Decrease In Contract With Customer Liability Accounts payable and other current liabilities Increase Decrease In Accounts Payable And Other Operating Liabilities Other long-term liabilities Increase Decrease In Other Noncurrent Liabilities Net cash used in operating activities Net Cash Provided By Used In Operating Activities CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided By Used In Investing Activities [Abstract] Purchases of equipment Payments To Acquire Property Plant And Equipment Net cash used in investing activities Net Cash Provided By Used In Investing Activities CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from issuance of exchangeable debt Proceeds From Issuance Of Exchangeable Debt Proceeds from issuance of common stock, net of transaction costs Proceeds From Issuance Of Common Stock Proceeds from issuance of common stock under employee stock purchase plan Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Proceeds from exercise of stock options, net of transaction costs Proceeds From Stock Options Exercised Payment of debt issuance costs Payments Of Debt Issuance Costs Payment of transaction costs for conversion of preferred stock Payments Of Stock Issuance Costs Repurchase of exchangeable senior notes, including transaction costs Repayments Of Convertible Debt Payment on long-term debt from royalty-bearing instrument Repayments Of Long Term Debt Transaction costs related to exchange of exchangeable senior notes Payments Of Debt Restructuring Costs Taxes paid related to stock-based awards Payments Related To Tax Withholding For Share Based Compensation Net cash provided by financing activities Net Cash Provided By Used In Financing Activities NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS AND RESTRICTED CASH Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, BEGINNING OF PERIOD Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations CASH AND CASH EQUIVALENTS AND RESTRICTED CASH, END OF PERIOD Supplemental disclosure of cash flow information: Supplemental Cash Flow Information [Abstract] Cash paid during the year for: Cash Paid During Period For [Abstract] Interest Interest Paid Net Income taxes Income Taxes Paid Supplemental disclosure of non-cash transactions: Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract] Exchange of exchangeable senior notes into common stock Debt Conversion Original Debt Amount1 Conversion of Series A Convertible Preferred Stock into common stock Conversion Of Stock Amount Converted1 Accounting Policies [Abstract] Nature of Business and Basis of Presentation Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block] Significant Accounting Policies Significant Accounting Policies [Text Block] Goodwill And Intangible Assets Disclosure [Abstract] Intangible Asset Intangible Assets Disclosure [Text Block] Inventory Disclosure [Abstract] Inventory Inventory Disclosure [Text Block] Property Plant And Equipment [Abstract] Property, Plant and Equipment Property Plant And Equipment Disclosure [Text Block] Discloses the breakout of accrued expenses and other liabilities that are not individually material for a separate caption on the statement of financial position between the current portion (payable within 12 months of year end or the operating cycle) and non-current (payable after 12 months from year end). Payables And Accruals [Abstract] Accrued Expenses and Other Current Liabilities Accrued Expenses And Other Liabilities Disclosure [Text Block] Debt Disclosure [Abstract] Debt Debt Disclosure [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] Equity [Abstract] Equity Stockholders Equity Note Disclosure [Text Block]