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Additional Paid in Capital, Other Decrease to additional paid-in capital for repurchase of conversion option in convertible notes Adjustments To Additional Paid In Capital Preferred Stock Purchase Option Adjustments To Additional Paid In Capital Preferred Stock Purchase Option Preferred stock purchase option Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation Adjustments to Additional Paid in Capital, Income Tax Benefit from Share-based Compensation Tax provision on stock-based compensation Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile loss to net cash used in operating activities: Agreement [Axis] Agreement [Axis] Agreement [Axis] Agreement [Domain] Agreement [Domain] Agreement [Domain] Allowance for Sales Returns [Member] Allowance for Sales Returns Allowance for Trade Receivables [Member] Allowance for Trade Receivables Allowances for Estimated Chargebacks Allowances for Estimated Chargebacks Chargebacks Allowances for Prompt Pay Discounts and DSA Allowances for Prompt Pay Discounts and DSA Trade allowances Amendment Flag Amendment Flag American Depositary Share American Depositary Share [Member] American Depositary Share American Depository Shares [Member] American Depository Shares [Member] American Depository Shares American Depository Shares to Shares Ratio American Depository Shares to Shares Ratio Number of shares that each ADS represents Amortization of Debt Discount (Premium) Interest expense, amortization of discount Amortization of Financing Costs and Discounts Amortization of debt discount and debt issuance costs Amortization of Intangible Assets Amortization of intangible asset Amount Of Potential Future Financial Obligations Amount Of Potential Future Financial Obligations Potential payment over the agreement terms Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Anti-dilutive securities Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Assets TOTAL ASSETS Assets [Abstract] ASSETS Assets, Current Total current assets Assets, Current [Abstract] Current Assets: Assets, Fair Value Disclosure [Abstract] Asset: Award Type [Axis] Award Type [Axis] Beneficial Ownership Limitation Percentage Beneficial Ownership Limitation Percentage Beneficial ownership limitation Biopharmaceutical [Member] Biopharmaceutical [Member] Biopharma Debt Bridge Loan [Member] Bridge Loan Business Development [Domain] Business Development [Domain] Business Development [Domain] Business Developments [Axis] Business Developments [Axis] Business Developments Cash and Cash Equivalents, at Carrying Value CASH AND CASH EQUIVALENTS, END OF PERIOD CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD Cash and cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Cash equivalents-money markets Cash and Cash Equivalents, Period Increase (Decrease) NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Cash Discount Invoice Terms Cash Discount Invoice Terms Sales discount term Cash Discount Percent Cash Discount Percent Sales discount percentage Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Non-cash transactions: Cash Paid During Period For [Abstract] Cash Paid During Period For [Abstract] Cash paid during the year for: Change In Control Obligations Change In Control Obligations Change of control obligation Charges Cash [Member] Charges Cash [Member] Cash Class of Stock [Domain] Class of Stock [Domain] Class Of Warrant Expiration Date Class Of Warrant Expiration Date Warrants expiration date Class of Warrant or Right [Axis] Class of Warrant or Right Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] Class of Warrant or Right, Exercised in Period Class of Warrant or Right, Exercised in Period Warrants exercised Class of Warrant or Right, Exercise Price of Warrants or Rights Exercise price of the warrants Class of Warrant or Right, Expired in Period Class of Warrant or Right, Expired in Period Warrants expired Class of Warrant or Right, Issued Class of Warrant or Right, Issued Number of warrants issued Class of Warrant or Right, Number of Securities Called by Each Warrant or Right Warrants issued, number of shares called by a warrant Class of Warrant or Right, Number of Securities Called by Warrants or Rights Warrants issued, number of shares called by the warrant Class of Warrant or Right, Outstanding Warrants outstanding Class of Warrant or Right, Term Class of Warrant or Right, Term Warrant term Collaborative Arrangement Disclosure [Text Block] Development, Commercialization and Supply Agreement Commitments and Contingencies Commitments and contingencies (Note 7) Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Line Items] Commitments and Contingencies Disclosure [Line Items] Commitments and Contingencies Disclosure [Line Items] Commitments and Contingencies Disclosure [Table] Commitments and Contingencies Disclosure [Table] Commitments and Contingencies Disclosure [Table] Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Common Stock [Member] Common Shares Common Stock, Par or Stated Value Per Share Common stock, par Common stock, par value Common Stock, Shares, Issued Common stock, issued Common Stock, Shares, Outstanding Common stock, outstanding Common Stock, Value, Issued Common stock, £0.50 par, unlimited authorized; 177,096,650 issued, 176,962,313 outstanding at March 31, 2015; 174,610,451 issued, 174,590,372 outstanding at December 31, 2014 Computer Equipment and Capitalized Software [Member] Computer Equipment and Capitalized Software [Member] Computer equipment and software Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Concentration Risk, Percentage Concentration risk percentage Concentration Risk Type [Domain] Concentration Risk Type [Domain] Concentrations Of Suppliers Policy [Text Block] Concentrations Of Suppliers Policy [Text Block] Concentration of Suppliers Consolidation, Policy [Policy Text Block] Principles of Consolidation Conversion Price Per Share Conversion Price Per Share Share conversion price Convertible Debt Convertible notes, carrying amount net of unamortized discount Convertible Debt [Member] Convertible Debt Convertible Preferred Stock, Shares Issued upon Conversion American depositary shares conversion rate to preference shares Co Promotion Agreement Disclosure [Text Block] Co Promotion Agreement Disclosure [Text Block] Co-Promotion Agreement Co-Promotion Agreement [Line Items] Co-Promotion Agreement [Line Items] Co-Promotion Agreement [Line Items] Co-Promotion Agreement [Table] Co-Promotion Agreement [Table] Co-Promotion Agreement [Table] Cost of Goods Sold Less: Cost of goods sold Credits/payments Made for Prior Period Sales Credits/payments Made for Prior Period Sales Credits/payments made for prior period sales Current Fiscal Year End Date Current Fiscal Year End Date Customer Concentration Risk [Member] Customer Concentration Risk Debt Conversion Description [Axis] Debt Conversion by Unique Description Debt Conversion, Converted Instrument, Shares Issued Convertible senior notes, total ADS into which the debt is exchangeable Debt Conversion, Name [Domain] Debt Conversion, Name [Domain] Debt Conversion, Original Debt, Amount Bridge notes converted in conjunction with the private placement, amount Debt Disclosure [Abstract] Debt Disclosure [Abstract] Debt Disclosure [Line Items] Debt Disclosure [Line Items] Debt Disclosure [Line Items] Debt Disclosure [Table] Debt Disclosure [Table] Debt Disclosure [Table] Debt Disclosure [Text Block] Debt Debt Exchange [Member] Debt Exchange [Member] Exchanged Debt Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Call Date, Earliest Convertible senior notes, earliest redemption date Debt Instrument, Convertible, Beneficial Conversion Feature BCF resulting from issuance of Series A Preference Shares Debt Instrument, Convertible, Conversion Price Bridge notes converted in conjunction with the private placement, price per share Convertible senior notes, initial exchange price Debt Instrument, Convertible, Conversion Ratio Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes Debt Instrument, Convertible, Remaining Discount Amortization Period Debt discount amortization period Debt Instrument, Convertible, Threshold Consecutive Trading Days Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price Debt Instrument, Convertible, Threshold Trading Days Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days Debt Instrument, Date of First Required Payment Convertible senior notes, payment start date Debt Instrument, Face Amount Convertible senior notes, principal amount Debt Instrument, Fair Value Disclosure Convertible senior notes, fair value Exchangeable senior notes, estimated fair value Debt Instrument, Interest Rate, Stated Percentage Convertible senior notes, stated interest rate Debt Instrument [Line Items] Debt Instrument [Line Items] Debt Instrument, Maturity Date Convertible senior notes, maturity date Debt Instrument Maturity Date Year Debt Instrument Maturity Date Year Convertible senior notes, due date Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Debt Instrument, Redemption Period, End Date Convertible senior notes redemption, end date Debt Instrument, Redemption Price, Percentage Convertible senior notes, repurchase price at option of the issuer Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Debt Instrument, Term Note, estimated remaining life Debt Instrument, Unamortized Discount Carrying value include debt discount Convertible senior notes, discount Debt Issuance Cost Underwriter's fees and offering costs Debt Issuance Costs Policy [Text Block] Debt Issuance Costs Policy [Text Block] Debt Issuance Costs Debt, Policy [Policy Text Block] Debt Instruments Deferred Income Tax Expense (Benefit) Deferred income taxes Deferred Revenue Deferred revenue Deferred Revenue Arrangement Type [Axis] Deferred Revenue Arrangement Type [Axis] Deferred Revenue [Domain] Deferred Revenue [Domain] Deferred Revenue, Current Deferred revenue Deferred Revenue, Noncurrent Deferred revenue Deferred Tax Assets, Net of Valuation Allowance, Current Deferred tax assets Deferred Tax Assets, Net of Valuation Allowance, Noncurrent Deferred tax assets Depreciation, Depletion and Amortization, Nonproduction Depreciation and amortization Derivative, by Nature [Axis] Derivative, by Nature Derivative Contract [Domain] Derivative Contract [Domain] Derivative Liability, Fair Value, Gross Liability Preferred stock purchase option derivative liability at fair value Derivative, Gain (Loss) on Derivative, Net Gain (loss) on change in fair value of derivatives Derivative Instrument [Axis] Derivative Instrument [Axis] Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Text Block] Warrants and Warrant Derivative Liability Derivative Liability Ending Balance Beginning Balance Derivative liability Derivative Liability, Current Warrant derivative liability Derivative Liability, Noncurrent Long-term debt derivative liabilities Derivative Liabilities Transferred to Equity Classifications Derivative Liabilities Transferred to Equity Classifications Transfer of preferred stock purchase option derivative liability to equity Derivative Liabilities Transferred to Stockholders' Equity Derivative Liabilities Transferred to Stockholders' Equity Transfer derivative liability to equity Transfer derivative liability to equity Derivative [Line Items] Derivative [Line Items] Derivative, Name [Domain] Derivative, Name [Domain] Derivatives, Fair Value [Line Items] Derivatives, Fair Value [Line Items] Derivatives, Policy [Policy Text Block] Derivative Instruments Derivative [Table] Derivative [Table] Dilutive Securities, Effect on Basic Earnings Per Share, Dilutive Convertible Securities Gain on warrant derivative liability Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Information [Table] Document Information [Table] Document Period End Date Document Period End Date Document Type Document Type Earnings Loss Per Share [Line Items] Earnings Loss Per Share [Line Items] Earnings Loss Per Share [Line Items] Earnings Loss Per Share [Table] Earnings Loss Per Share [Table] Earnings Loss Per Share [Table] Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share, Basic Basic Net loss per share-basic Earnings Per Share, Basic and Diluted [Abstract] Loss per share: Earnings Per Share, Diluted Diluted Net income loss per share-diluted Earnings Per Share, Policy [Policy Text Block] Loss per Share Eddingpharm [Member] Eddingpharm [Member] Eddingpharm Eligible Milestone Payment Eligible Milestone Payment Additional upfront payment eligible to receive based on development, regulatory and sales Milestone Embedded Derivative, Description of Host Contract Description of pricing variability feature and classification of warrants Embedded Derivative, Fair Value of Embedded Derivative Liability Fair value of embedded derivative liability Long term debt redemption feature Embedded Derivative Financial Instruments [Member] Embedded Derivative Financial Instruments Employee Stock Option [Member] Stock Options Energy [Axis] Instrument Energy [Domain] Energy [Domain] Entity Central Index Key Entity Central Index Key Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Entity [Domain] Entity [Domain] Entity Filer Category Entity Filer Category Entity Registrant Name Entity Registrant Name Equity [Abstract] Equity [Abstract] Equity Component [Domain] Equity Component [Domain] Development Stage Entities, Equity Issuance, Per Share Amount Common stock issued under private placement, price per share Excess Principal Value Over Fair Value Excess Principal Value Over Fair Value Value of shares in excess of principal amount of Notes based on closing price Excess Tax Benefit from Share-based Compensation, Financing Activities Excess provision on stock-based awards Excess Tax Benefit from Share-based Compensation, Operating Activities Excess tax provision on stock-based awards Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table Text Block] Assets and Liability Measured at Fair Value on a Recurring Basis Fair Value Assumptions, Comparable Yield to Maturity Fair Value Assumptions, Comparable Yield to Maturity Derivative liability fair value assumptions, market yields Fair Value Assumptions Coupon Rate Fair Value Assumptions Coupon Rate Derivative liability fair value assumption, coupon rate Fair Value Assumptions, Expected Dividend Rate Derivative liability fair value assumptions, dividend yield Fair Value Assumptions, Expected Term Derivative liability fair value assumptions, term Fair Value Assumptions, Expected Volatility Rate Derivative liability fair value assumptions, volatility rate Fair Value Assumptions, Risk Free Interest Rate Derivative liability fair value assumptions, risk-free rate Fair Value, Hierarchy [Axis] Fair Value, Hierarchy Measurement Frequency [Axis] Fair Value by Measurement Frequency Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Fair Value, Inputs, Level 1 [Member] Level 1 Fair Value, Inputs, Level 3 [Member] Level 3 Fair Value, Measurement Frequency [Domain] Fair Value, Measurement Frequency [Domain] Fair Value Hierarchy [Domain] Fair Value Hierarchy [Domain] Fair Value, Measurements, Recurring [Member] Fair Value, Measurements, Recurring Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] Fair Values Derivatives, Balance Sheet Location, by Derivative Contract Type [Table] Finance [Member] Finance [Member] Finance Finite-Lived Intangible Assets, Accumulated Amortization Accumulated amortization Finite-Lived Intangible Assets, Gross Technology rights Finite-Lived Intangible Assets [Line Items] Finite-Lived Intangible Assets [Line Items] Finite-Lived Intangible Assets, Net Intangible asset, net Intangible asset, net Finite-Lived Intangible Asset, Useful Life Intangible assets estimated remaining useful life Foreign Currency Transactions and Translations Policy [Policy Text Block] Foreign Currency Furniture and Fixtures [Member] Furniture and Fixtures Further Indication for AMR101 [Member] Further Indication for AMR101 [Member] Further Indication for AMR101 Future Minimum Guarantee Payments Future Minimum Guarantee Payments Future minimum repayment under agreement Gain (Loss) on Derivative Instruments, Net, Pretax Gain (Loss) on change in fair value of derivative liability Gains (Losses) on Extinguishment of Debt Gain on extinguishment of debt Goodwill and Intangible Assets Disclosure [Abstract] Goodwill and Intangible Assets Disclosure [Abstract] Gross Profit Gross margin Guarantee Payments Guarantee Payments Repayment under agreement Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Long-Lived Asset Impairment Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Loss from operations before taxes Income Statement [Abstract] Income Statement [Abstract] Income Taxes Paid Income taxes Income Tax Expense (Benefit) Benefit from (provision for) income taxes Income Tax, Policy [Policy Text Block] Income Taxes Increase (Decrease) in Accounts Payable and Other Operating Liabilities Accounts payable and other current liabilities Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Deferred Revenue Deferred revenue Increase (Decrease) in Derivative Liabilities Increase (Decrease) in the fair value of warrant derivative liability Record derivative liability Increase (Decrease) in Interest Payable, Net Accrued interest payable Increase (Decrease) in Inventories Inventories Increase (Decrease) in Operating Capital [Abstract] Changes in assets and liabilities: Increase (Decrease) in Other Noncurrent Assets Other non-current assets Increase (Decrease) in Other Noncurrent Liabilities Other non-current liabilities Increase (Decrease) in Prepaid Expense and Other Assets Prepaid and other current assets Increase (Decrease) in Restricted Cash Restricted cash Incremental Common Shares Attributable to Dilutive Effect of Call Options and Warrants Effect of dilutive warrants Intangible Assets Disclosure [Line Items] Intangible Assets Disclosure [Line Items] Intangible Assets Disclosure [Line Items] Intangible Assets Disclosure [Table] Intangible Assets Disclosure [Table] Intangible Assets Disclosure [Table] Intangible Assets Disclosure [Text Block] Intangible Assets Intangible Assets, Finite-Lived, Policy [Policy Text Block] Intangible Asset, net Interest Expense Interest expense Interest Expense, Debt Convertible notes, interest expense Interest Expense, Debt, Excluding Amortization Interest expense, contractual coupon interest accrual Interest Income (Expense), Nonoperating, Net Interest expense, net Interest Paid Interest Interest payment on notes Interest Payable, Current Accrued interest on convertible note Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Inventory Disclosure [Text Block] Inventory Inventory, Finished Goods, Net of Reserves Finished goods Inventory [Line Items] Inventory [Line Items] Inventory, Net Inventory Inventory, Policy [Policy Text Block] Inventory Inventory, Raw Materials, Net of Reserves Raw materials Inventory [Table] Inventory [Table] Inventory [Table] Inventory, Work in Process, Net of Reserves Work in process Kowa Pharmaceuticals America [Member] Kowa Pharmaceuticals America [Member] Kowa Pharmaceuticals America Laxdale Limited [Member] Laxdale Limited [Member] Laxdale Limited Leasehold Improvements [Member] Leasehold improvements Legal Entity [Axis] Legal Entity [Axis] Liabilities Total liabilities Liabilities and Equity TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' DEFICIT Liabilities, Current Total current liabilities Liabilities, Current [Abstract] Current Liabilities: Liabilities, Fair Value Disclosure [Abstract] Liabilities: Liabilities For Commitments [Axis] Liabilities For Commitments [Axis] Liabilities For Commitments [Axis] Liabilities For Commitments [Domain] Liabilities For Commitments [Domain] Liabilities For Commitments [Domain] Liabilities, Noncurrent [Abstract] Long-Term Liabilities: License And Collaboration Agreements [Line Items] License And Collaboration Agreements [Line Items] License And Collaboration Agreements [Line Items] License And Collaboration Agreements [Table] License And Collaboration Agreements [Table] License And Collaboration Agreements [Table] Licenses Revenue Licensing revenue Litigation and Contingencies, Policy [Text Block] Litigation and Contingencies, Policy [Text Block] Costs for Patent Litigation and Legal Proceedings Long-term Debt, Current Maturities Current portion of long-term debt Long-term Debt, Fair Value Long term debt-December 2012 financing, estimated fair value Long-term Debt, Excluding Current Maturities Long term debt-December 2012 financing, carrying value Long-term debt Long Term Debt [Policy Text Block] Long Term Debt [Policy Text Block] Long-Term Debt Redemption Features Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Customer [Axis] Customer [Axis] Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Axis] Major Types of Debt and Equity Securities [Domain] Major Types of Debt and Equity Securities [Domain] Marketing Agreement [Axis] Marketing Agreement [Axis] Marketing Agreement [Axis] Marketing Agreement [Domain] Marketing Agreement [Domain] Marketing Agreement [Domain] Maturity Period Used to Classify Investments Maturity Period Used to Classify Investments Short term highly liquid instruments, maturity date Maximum [Member] Maximum Minimum [Member] Minimum Customer [Domain] Customer [Domain] Negotiated Purchase Price Per Unit Negotiated Purchase Price Per Unit Share, negotiated price Net Cash Provided by (Used in) Financing Activities [Abstract] CASH FLOWS FROM FINANCING ACTIVITIES: Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Net Cash Provided by (Used in) Investing Activities [Abstract] CASH FLOWS FROM INVESTING ACTIVITIES: Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Operating Activities [Abstract] CASH FLOWS FROM OPERATING ACTIVITIES: Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Income (Loss) Attributable to Parent Loss for the period Net loss Net loss Net Income (Loss) Available to Common Stockholders, Basic Net loss applicable to common shareholders-basic Net loss applicable to common shareholders Net Income (Loss) Available to Common Stockholders, Diluted Net loss-diluted New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Non Cash [Member] Non Cash [Member] Non Cash Non Refundable Upfront Payments Received Non Refundable Upfront Payments Received Non-refundable up-front received Number of Operating Segments Number of operating segments Number Of Sales Representative Number Of Sales Representative Number of sales representatives October 2009 Private Placement [Member] October 2009 Private Placement [Member] October 2009 Private Placement Officer [Member] Warrants issued to three former officers Operating Expenses Total operating expenses Operating Expenses [Abstract] Operating expenses: Operating Income (Loss) Operating loss Ordinary Shares Ordinary Shares [Member] Ordinary Shares Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Table] Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Nature of Business and Basis of Presentation Other Assets, Noncurrent Other non-current assets Other Commitment Maximum repayment of future revenue and receivables Other Debt Obligations [Member] Other Debt Obligations [Member] Other debt outstanding Other Estimated Offering Costs Other Estimated Offering Costs Estimated offering expense Other Incentive Programs [Member] Other Incentive Programs [Member] Other Incentive Programs Other Liabilities, Noncurrent Other long-term liabilities Other Nonoperating Income (Expense) Other (expense) income, net Payments for Repurchase of Common Stock Acquisition of treasury stock Percentage Representation Of Common Stock Outstanding Upon Conversion Percentage Representation Of Common Stock Outstanding Upon Conversion Preference shares conversion rate to ordinary share Period [Axis] Period [Axis] Period Period [Domain] Period [Domain] Period [Domain] Period 4 [Member] Period 4 [Member] Final Payment Period 1 [Member] Period 1 [Member] May 2015 Period 3 [Member] Period 3 [Member] Per quarter in each of the next four quarters Period 2 [Member] Period 2 [Member] Third quarter of 2015 and in each of the next two quarters Plan Name [Axis] Plan Name [Axis] Plan Name [Domain] Plan Name [Domain] Potential Marketing Approval 1 [Member] Potential Marketing Approval 1 [Member] Potential Marketing Approval 1 Potential Marketing Approval 2 [Member] Potential Marketing Approval 2 [Member] Potential Marketing Approval 2 Preferred Stock Dividends and Other Adjustments Preferred stock purchase option Preferred stock purchase option (see Note 8) Preferred Stock [Member] Preferred Shares Preferred Stock Preferred Stock, Par or Stated Value Per Share Preference Shares, par value Preferred stock, par value Preferred Stock Purchase Option [Member] Preferred Stock Purchase Option [Member] Preferred Stock Purchase Option Preferred Stock, Shares Issued Preferred shares, issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Preferred Stock, Value, Issued Series A Convertible Preferred Stock, £0.05 par, unlimited authorized; 352,150,790 issued and outstanding at March 31, 2015 (equivalent to 35,215,079 ordinary shares upon future consolidation and redesignation at a 10:1 ratio); zero shares issued and outstanding at December 31, 2014 Prepaid Expense and Other Assets, Current Prepaid and other current assets Prior To Agreement [Member] Prior To Agreement [Member] Prior To Agreement Private Placement Closing Date Private Placement Closing Date Private placement, closing date Proceeds from Convertible Debt Convertible senior notes, net proceeds Proceeds from Debt, Net of Issuance Costs Proceeds allocated to conversion option Proceeds from Issuance of Preferred Stock and Preference Stock Proceeds from issuance of preferred stock, net of transaction costs Proceeds from Issuance of Private Placement Aggregate gross proceeds Common stock issued under private placement, net proceeds Proceeds from (Payments for) Other Financing Activities Amount received at the closing of the agreement Proceeds from Stock Options Exercised Proceeds from exercise of stock options, net of transaction costs Proceeds from Warrant Exercises Proceed from exercise of warrants Proceeds from exercise of warrants, net of transaction costs Proceeds from Warrant Exercises Gross Proceeds from Warrant Exercises Gross Proceeds from exercise of warrants, gross of transaction costs Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Property, Plant and Equipment, Type [Axis] Property, Plant and Equipment by Type Property, Plant and Equipment, Estimated Useful Lives Property Plant and Equipment Useful Life Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Property, Plant and Equipment, Net Property, plant and equipment, net Property, Plant and Equipment, Policy [Policy Text Block] Property, Plant and Equipment Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Type [Domain] Property, Plant and Equipment, Useful Life Property Plant and Equipment Useful Life Property, Plant and Equipment, Useful Life [Table Text Block] Property, Plant and Equipment, Useful Life [Table Text Block] Estimated Useful Lives Provision Related to Prior Period Sales Provision Related to Prior Period Sales Provision related to prior period sales Range [Axis] Range Range [Domain] Range [Domain] Range of Percentage of Gross Margin Payable for Co-Promotion Agreement Range of Percentage of Gross Margin Payable for Co-Promotion Agreement Promotion fee as a percentage gross margin Rebates Chargebacks And Discounts [Member] Rebates Chargebacks And Discounts [Member] Rebates Chargebacks And Discounts Receivables, Policy [Policy Text Block] Accounts Receivable, net Related Party [Domain] Related Party [Domain] Related Party Transactions [Abstract] Related Party Transactions [Abstract] Related Party [Axis] Related Party Transactions, by Related Party Repayments of Long-term Capital Lease Obligations Payments under capital leases Research and Development Expense Research and development Research and Development Expense, Policy [Policy Text Block] Research and Development Costs Restricted Cash and Cash Equivalents, Current Restricted cash Restricted Stock and Restricted Stock Units [Member] Restricted Stock and Restricted Stock Units [Member] Restricted Stock and Restricted Stock Units Restricted Stock Units (RSUs) [Member] Restricted Stock Units (RSUs) Retained Earnings (Accumulated Deficit) Accumulated deficit Retained Earnings [Member] Accumulated Deficit Revenue Recognition, Policy [Policy Text Block] Revenue Recognition Royalty Guarantees, Commitments, Amount Potential aggregate stock or cash payment Sale of Stock [Domain] Sale of Stock [Domain] Sales Revenue, Goods, Net Product revenue, net Revenue, Net Total revenue, net Sales Revenue, Net [Member] Gross Product Sales Scenario, Unspecified [Domain] Scenario, Unspecified [Domain] Schedule of Accounts, Notes, Loans and Financing Receivable [Table] Schedule of Accounts, Notes, Loans and Financing Receivable [Table] Schedule of Accounts, Notes, Loans and Financing Receivable [Table Text Block] Summarizes the Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Anti-Dilutive Securities Not Included in the Computation of Net Loss per Share Schedule of Carrying Values and Estimated Fair Values of Debt Instruments [Table Text Block] Carrying Amounts and Estimated Fair Values of Debt Instruments Schedule of Derivative Liabilities at Fair Value [Table Text Block] Change in Fair Value of Derivative Liabilities Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Net Income Loss and the Number of Shares Used to Compute Basic and Diluted Earnings per Share Schedule of Finite-Lived Intangible Assets [Table] Schedule of Finite-Lived Intangible Assets [Table] Schedule of Finite-Lived Intangible Assets [Table Text Block] Schedule of Carrying Value of Intangible Asset Schedule of Inventory, Current [Table Text Block] Schedule of Inventory Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Securities Financing Transaction [Axis] Securities Financing Transaction [Axis] Securities Financing Transaction [Domain] Securities Financing Transaction [Domain] Segments [Domain] Segments [Domain] Segment Reporting, Policy [Policy Text Block] Segment and Geographical Information Selling, General and Administrative Expense Selling, general and administrative Selling, General and Administrative Expenses, Policy [Policy Text Block] Selling, General and Administrative Costs Senior Notes, Noncurrent Exchangeable senior notes, net of discount Senior Notes Exchangeable senior notes, carrying value Senior Notes One [Member] Senior Notes One [Member] 2012 Notes Senior Notes Two [Member] Senior Notes Two [Member] 2014 Notes Series A Preferred Stock [Member] Series A Preferred Stock Share-based Compensation Compensation income for change in fair value of warrants issued to former employees Stock-based compensation Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period Stock options, Vesting Period Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Stock units, Granted Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures Granted options Equity Award [Domain] Equity Award [Domain] Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Stock-Based Compensation Share Price Market value, per share Share Repurchase Program Additional Authorized Amount Share Repurchase Program Additional Authorized Amount Additional shares purchase amount Shares, Outstanding Ending Balance (in shares) Beginning Balance (in shares) Shipping and Handling Cost, Policy [Policy Text Block] Distribution Costs Significant Accounting Policies [Line Items] Significant Accounting Policies [Line Items] Significant Accounting Policies [Line Items] Significant Accounting Policies [Table] Significant Accounting Policies [Table] Significant Accounting Policies [Table] Significant Accounting Policies [Text Block] Significant Accounting Policies Segments [Axis] Segments [Axis] Class of Stock [Axis] Class of Stock [Axis] Equity Components [Axis] Statement, Equity Components Statement [Line Items] Statement [Line Items] Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Scenario [Axis] Statement, Scenario Statement [Table] Statement [Table] Stockholders' Equity Attributable to Parent Ending Balance Beginning Balance Total stockholders' deficit Stockholders' Equity Attributable to Parent [Abstract] Stockholders' Deficit: Stockholders' Equity Note Disclosure [Text Block] Equity Stockholders Equity Note [Line Items] Stockholders Equity Note [Line Items] Stockholders Equity Note [Line Items] Stockholders Equity Note [Table] Stockholders Equity Note [Table] Stockholders Equity Note [Table] Stock Incentive Plan 2011 [Member] Stock Incentive Plan 2011 [Member] Stock Incentive Plan 2011 Stock Issued During Period Share Exercise Of Stock Options Vesting Of Restricted Stock Stock Issued During Period Share Exercise Of Stock Options Vesting Of Restricted Stock Shares issued, related to the vesting of RSUs Stock Issued During Period, Shares, New Issues Common stock issued under private placement, shares Issuance of Series A Convertible Preferred Stock, net (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Vesting of restricted stock units (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercise of stock options (in shares) Shares issued, exercise of stock options Number of shares issued during the period as a result of the exercise of warrants. Stock Issued During Period, Shares, Warrants Exercised Exercise of warrants (in shares) Shares issued, exercise of warrants Stock Issued During Period, Value, New Issues Stock issued under private placement, value Common stock issued under private placement, value Issuance of Series A Convertible Preferred Stock, net Stock Issued During Period, Value, Restricted Stock Award, Net of Forfeitures Vesting of restricted stock units Stock Issued During Period, Value, Stock Options Exercised Exercise of stock options Value stock issued during the period as a result of the exercise of warrants. Stock Issued During Period, Value, Warrants Exercised Exercise of warrants Equity Option [Member] Stock options Stock Options And Restricted Stock Units [Member] Stock Options And Restricted Stock Units [Member] Options and Restricted Stock Units Stock Repurchase Program, Number of Shares Authorized to be Repurchased Share maximum amount Subsequent Event [Member] Subsequent Event Subsequent Events [Abstract] Subsequent Events [Abstract] Subsequent Events [Text Block] Subsequent Events Subsequent Event Type [Axis] Subsequent Event Type Subsequent Event Type [Domain] Subsequent Event Type [Domain] Sale of Stock [Axis] Subsidiary, Sale of Stock Summary Of Valuation Allowances Table [Text Block] Summary Of Valuation Allowances Table [Text Block] Summarizes Activity of the Net Product Revenue Allowance and Reserve Categories Supplemental Cash Flow Information [Abstract] Supplemental disclosure of cash flow information: Tax Sharing Agreement Obligation [Member] Tax Sharing Agreement Obligation [Member] Employee tax obligations Text Block [Abstract] Text Block [Abstract] Top 3 Customer [Member] Top 3 Customer [Member] Top Three Customers Total Inventory Net Total Inventory Net Total inventory Trading Symbol Trading Symbol Treasury Stock [Member] Treasury Shares Treasury Stock, Shares Treasury shares Treasury stock, shares Treasury Stock, Value Treasury stock; 134,337 shares at March 31, 2015; 20,079 shares at December 31, 2014 Typeof Obligation [Axis] Typeof Obligation [Axis] Typeof Obligation [Axis] Typeof Obligation [Domain] Typeof Obligation [Domain] Typeof Obligation [Domain] Unrealized Gain (Loss) on Derivatives Gain (loss) on change in fair value of derivative liability Gain on change in fair value of derivative liabilities Gain on change in fair value of derivative liabilities Gain on changes in fair value of derivative liabilities Unrealized Gain on Derivatives Unrealized Gain on Derivatives Gain (loss) on change in fair value of derivative liability Up-front Payment Arrangement [Member] Up-front Payment Use of Estimates, Policy [Policy Text Block] Use of Estimates Use of Forecasted Financial Information in Accounting Estimates [Policy Text Block] Use of Forecasted Financial Information in Accounting Estimates [Policy Text Block] Use of Forecasted Financial Information in Accounting Estimates Valuation Allowances and Reserves, Balance Ending balance Beginning balance Valuation Allowances and Reserves, Charged to Cost and Expense Provision related to current period and deferred sales Valuation Allowances and Reserves, Deductions Credits/payments made for current period and deferred sales Valuation Allowances and Reserves [Domain] Valuation Allowances and Reserves [Domain] Valuation Allowances and Reserves Type [Axis] Valuation Allowances and Reserves Type [Axis] Valuation and Qualifying Accounts [Abstract] Valuation and Qualifying Accounts [Abstract] Valuation and Qualifying Accounts Disclosure [Line Items] Valuation and Qualifying Accounts Disclosure [Line Items] Valuation and Qualifying Accounts Disclosure [Table] Valuation and Qualifying Accounts Disclosure [Table] Warrant [Member] Warrant Warrants Issued July 2009 [Member] Warrants Issued July 2009 [Member] Warrants Issued July 2009 Warrants Issued October 2009 [Member] Warrants Issued October 2009 [Member] Warrants Issued October 2009 Weighted Average Number Basic And Diluted, Shares Outstanding [Abstract] Weighted Average Number Basic And Diluted, Shares Outstanding [Abstract] Weighted average shares: Weighted Average Number of Shares Outstanding, Diluted Diluted Weighted average shares outstanding-diluted Weighted Average Number of Shares Outstanding, Basic Basic Weighted average shares outstanding-basic Write Offs Of Accounts Receivables Write Offs Of Accounts Receivables Accounts receivable written off