Accounting Policies [Abstract] Accounting Policies [Abstract] Accounting Standards Update 2015-03 [Member] Accounting Standards Update 2015-03 Accounting Standards Update 2016-09 [Member] Accounting Standards Update 2016-09 [Member] ASU No. 2016-09 Accounts, Notes, Loans and Financing Receivable [Line Items] Accounts, Notes, Loans and Financing Receivable [Line Items] Accounts Payable, Current Accounts payable Accounts Receivable Credit Period Accounts Receivable Credit Period Trade receivables, credit period Accounts Receivable, Gross, Current Gross trade accounts receivable Accounts Receivable [Member] Accounts Receivable Accounts Receivable, Net, Current Accounts receivable, net Accounts receivable, net Accrued Liabilities and Other Liabilities Accrued expenses and other current liabilities Additional Paid in Capital, Common Stock Additional paid-in capital Additional Paid-in Capital [Member] Additional Paid-in Capital Additional Percentage Interest Rate Penalty Additional Percentage Interest Rate Penalty Additional interest rate on notes per annum Adjustments for New Accounting Pronouncements [Axis] Adjustments for New Accounting Pronouncements [Axis] Adjustments to Additional Paid in Capital, Convertible Debt with Conversion Feature Decrease to additional paid-in capital for repurchase of conversion option in convertible notes Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Allowance for Estimated Chargebacks [Member] Allowance for Estimated Chargebacks [Member] Chargebacks Allowance for Sales Returns [Member] Allowance for Sales Returns Allowance for Trade Receivables [Member] Trade Receivables Amendment Flag Amendment Flag American Depositary Share American Depositary Share [Member] American Depositary Share American Depository Shares [Member] American Depository Shares [Member] American Depository Shares American Depository Shares to Shares Ratio American Depository Shares to Shares Ratio Number of shares that each ADS represents Amortization of Debt Issuance Costs and Discounts Amortization of debt discount and debt issuance costs Amortization of Intangible Assets Amortization of intangible asset Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Anti-dilutive securities Antidilutive Securities [Axis] Antidilutive Securities [Axis] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Arrangements and Non-arrangement Transactions [Domain] Arrangements and Non-arrangement Transactions [Domain] Assets TOTAL ASSETS Assets [Abstract] ASSETS Assets, Current Total current assets Total current assets Assets, Current [Abstract] Current Assets: Assets, Fair Value Disclosure [Abstract] Asset: Award Type [Axis] Award Type [Axis] Beneficial Conversion Feature [Policy Text Block] Beneficial Conversion Feature [Policy Text Block] Beneficial Conversion Features Beneficial Ownership Limitation Percentage Beneficial Ownership Limitation Percentage Beneficial ownership limitation Biopharmaceutical [Member] Biopharmaceutical [Member] BioPharma Debt Bridge Loan [Member] Bridge Loan Business Development [Domain] Business Development [Domain] Business Development [Domain] Business Developments [Axis] Business Developments [Axis] Business Developments Cash and Cash Equivalents, at Carrying Value CASH AND CASH EQUIVALENTS, END OF PERIOD CASH AND CASH EQUIVALENTS, BEGINNING OF PERIOD Cash and cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Cash equivalents-money markets Cash and Cash Equivalents, Period Increase (Decrease) NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents and Restricted Cash Cash Discount Invoice Terms Cash Discount Invoice Terms Sales discount term Cash Discount Percent Cash Discount Percent Sales discount percentage Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Non-cash transactions: Cash Paid During Period For [Abstract] Cash Paid During Period For [Abstract] Cash paid during the year for: Charges Cash [Member] Charges Cash [Member] Cash Class of Stock [Domain] Class of Stock [Domain] Class of Warrant or Right [Axis] Class of Warrant or Right Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] Class of Warrant or Right, Exercised in Period Class of Warrant or Right, Exercised in Period Warrants exercised Class of Warrant or Right, Exercise Price of Warrants or Rights Exercise price of the warrants Class of Warrant or Right, Expired in Period Class of Warrant or Right, Expired in Period Warrants expired Class of Warrant or Right, Issued Class of Warrant or Right, Issued Number of warrants issued Class of Warrant or Right, Number of Securities Called by Each Warrant or Right Warrants issued, number of shares called by a warrant Class of Warrant or Right, Number of Securities Called by Warrants or Rights Warrants issued, number of shares called by the warrant Class of Warrant or Right, Outstanding Warrants outstanding Class of Warrant or Right, Term Class of Warrant or Right, Term Warrant term Clinical Trial Application Clinical Trial Application [Member] Clinical Trial Application Collaborative Arrangement Disclosure [Text Block] Development, Commercialization and Supply Agreement Commitments and Contingencies Commitments and contingencies (Note 7) Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Line Items] Commitments and Contingencies Disclosure [Line Items] Commitments and Contingencies Disclosure [Line Items] Commitments and Contingencies Disclosure [Table] Commitments and Contingencies Disclosure [Table] Commitments and Contingencies Disclosure [Table] Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Common Stock [Member] Common Shares Common Stock, Par or Stated Value Per Share Common stock, par value Common Stock, Shares, Issued Common stock, issued Common Stock, Shares, Outstanding Common stock, outstanding Common Stock, Value, Issued Common stock, £0.50 par, unlimited authorized; 185,274,511 issued, 184,551,164 outstanding as of June 30, 2016; 183,577,765 issued, 183,403,263 outstanding as of December 31, 2015 Computer Equipment and Capitalized Software [Member] Computer Equipment and Capitalized Software [Member] Computer equipment and software Concentration Of Suppliers [Policy Text Block] Concentration Of Suppliers [Policy Text Block] Concentration of Suppliers Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Concentration Risk Type [Axis] Concentration Risk Type [Axis] Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Concentration Risk, Percentage Concentration risk percentage Concentration Risk Type [Domain] Concentration Risk Type [Domain] Consolidation, Policy [Policy Text Block] Principles of Consolidation Conversion of Stock, Amount Converted Conversion of Series A Convertible Preferred Stock into common stock Conversion Price Per Share Conversion Price Per Share Share conversion price Convertible Debt Convertible notes, carrying amount net of unamortized discount Convertible Debt [Member] Convertible Debt Convertible Preferred Stock, Shares Issued upon Conversion Number of shares issued for each preference shares Co Promotion Agreement Disclosure [Text Block] Co Promotion Agreement Disclosure [Text Block] Co-Promotion Agreement Co-Promotion Agreement [Line Items] Co-Promotion Agreement [Line Items] Co-Promotion Agreement [Line Items] Co Promotion Agreement [Member] Co Promotion Agreement [Member] Co-Promotion Agreement (the Agreement) Co-Promotion Agreement [Table] Co-Promotion Agreement [Table] Co-Promotion Agreement [Table] Cost of Goods Sold Less: Cost of goods sold Credits/payments Made for Prior Period Sales Credits/payments Made for Prior Period Sales Credits/payments made for prior period sales Cumulative Effect on Retained Earnings, Net of Tax Cumulative-effect adjustment Current Fiscal Year End Date Current Fiscal Year End Date Customer Concentration Risk [Member] Customer Concentration Risk Date One [Member] Date One [Member] Date One Date Three [Member] Date Three [Member] Date Three Date Two [Member] Date Two [Member] Date Two Debt Conversion Description [Axis] Debt Conversion by Unique Description Debt Conversion, Name [Domain] Debt Conversion, Name [Domain] Debt Conversion, Original Debt, Amount Bridge notes converted in conjunction with the private placement, amount Debt Disclosure [Abstract] Debt Disclosure [Abstract] Debt Disclosure [Line Items] Debt Disclosure [Line Items] Debt Disclosure [Line Items] Debt Disclosure [Table] Debt Disclosure [Table] Debt Disclosure [Table] Debt Disclosure [Text Block] Debt Debt Exchange [Member] Debt Exchange [Member] Exchanged Debt Debt Instrument [Axis] Debt Instrument [Axis] Debt Instrument, Call Date, Earliest Convertible senior notes, earliest redemption date Debt Instrument, Call Date, Latest Convertible senior notes, latest redemption date Debt Instrument, Convertible, Carrying Amount of Equity Component Carrying amount of debt conversion option over the liability component Debt Instrument, Convertible, Conversion Price Bridge notes converted in conjunction with the private placement, price per share Convertible senior notes, initial exchange price Debt Instrument, Convertible, Conversion Ratio Convertible senior notes, exchange rate of ADS per $1,000 principal amount of notes Debt Instrument, Convertible, Number of Equity Instruments Convertible senior notes, total ADS into which the debt is exchangeable Debt Instrument, Convertible, Threshold Consecutive Trading Days Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, at least number of VWAP Trading days Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price Debt Instrument, Convertible, Threshold Trading Days Convertible senior notes, mandatory exchange in whole or in part if daily VWAP equals or exceeds percentage of exchange price, in any number of VWAP Trading days Debt Instrument, Date of First Required Payment Convertible senior notes, payment start date Debt Instrument, Face Amount Convertible senior notes, principal amount Debt Instrument, Fair Value Disclosure Convertible senior notes, fair value Exchangeable senior notes, estimated fair value Debt Instrument, Interest Rate, Stated Percentage Convertible senior notes, stated interest rate Debt Instrument [Line Items] Debt Instrument [Line Items] Debt Instrument, Maturity Date Convertible senior notes, maturity date Debt Instrument Maturity Date Year Debt Instrument Maturity Date Year Convertible senior notes, due date Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Debt Instrument, Redemption Period, End Date Convertible senior notes redemption, end date Debt Instrument, Redemption Price, Percentage Convertible senior notes, repurchase price at option of the issuer Debt Instrument, Repurchased Face Amount Convertible senior notes, principal amount purchase Schedule of Long-term Debt Instruments [Table] Schedule of Long-term Debt Instruments [Table] Debt Instrument, Term Note, estimated remaining life Note, expected term Debt Instrument, Unamortized Discount Convertible senior notes, discount Debt Issuance Costs [Policy Text Block] Debt Issuance Costs [Policy Text Block] Debt Issuance Costs Debt, Policy [Policy Text Block] Debt Instruments Debt Issuance Costs, Gross Offering costs Deferred Income Tax Expense (Benefit) Deferred income taxes Deferred Revenue Deferred revenue Deferred Revenue Arrangement Type [Axis] Deferred Revenue Arrangement Type [Axis] Deferred Revenue [Domain] Deferred Revenue [Domain] Deferred Revenue, Current Deferred revenue, current Deferred Revenue, Noncurrent Deferred revenue, long-term Deferred Tax Assets, Net Deferred tax assets Deferred Tax Assets, Net of Valuation Allowance, Noncurrent Deferred tax assets Depreciation Depreciation Derivative Contract [Domain] Derivative Contract [Domain] Derivative Liability, Fair Value, Gross Liability Derivative liability at fair value Derivative, Gain (Loss) on Derivative, Net Gain (loss) on change in fair value of derivatives Derivative Instrument [Axis] Derivative, by Nature Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Text Block] Warrants and Warrant Derivative Liability Derivative Liability Ending Balance Beginning Balance Derivative Liability, Noncurrent Long-term debt derivative liabilities Derivative Liabilities Transferred To Equity Classifications Derivative Liabilities Transferred To Equity Classifications Transfer of preferred stock purchase option derivative liability to equity Derivative Liabilities Transferred to Stockholders' Equity Derivative Liabilities Transferred to Stockholders' Equity Transfer derivative liability to equity Transfer derivative liability to equity Derivative [Line Items] Derivative [Line Items] Derivatives, Fair Value [Line Items] Derivatives, Fair Value [Line Items] Derivatives, Policy [Policy Text Block] Derivative Liabilities Derivative [Table] Derivative [Table] Dilutive Securities, Effect on Basic Earnings Per Share, Dilutive Convertible Securities Gain on warrant derivative liability Director [Member] Director Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document And Entity Information [Abstract] Document Fiscal Period Focus Document Fiscal Period Focus Document Fiscal Year Focus Document Fiscal Year Focus Document Information [Line Items] Document Information [Line Items] Document Information [Table] Document Information [Table] Document Period End Date Document Period End Date Document Type Document Type Earnings Loss Per Share [Line Items] Earnings Loss Per Share [Line Items] Earnings Loss Per Share [Line Items] Earnings Loss Per Share [Table] Earnings Loss Per Share [Table] Earnings Loss Per Share [Table] Earnings Per Share [Abstract] Earnings Per Share [Abstract] Earnings Per Share, Basic Basic Earnings Per Share, Basic and Diluted Net loss per share-basic and diluted Earnings Per Share, Basic and Diluted [Abstract] Loss per share: Earnings Per Share, Diluted Diluted Earnings Per Share, Policy [Policy Text Block] Loss per Share Eddingpharm [Member] Eddingpharm [Member] Eddingpharm Eligible Milestone Payment Eligible Milestone Payment Additional upfront payment eligible to receive based on development, regulatory and sales Milestone Embedded Derivative, Description of Host Contract Description of pricing variability feature and classification of warrants Embedded Derivative, Fair Value of Embedded Derivative Liability Fair value of embedded derivative liability Embedded Derivative Financial Instruments [Member] Embedded Derivative Financial Instruments Employee Stock Option [Member] Stock Options Energy [Axis] Instrument Energy [Domain] Energy [Domain] Entity Central Index Key Entity Central Index Key Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Entity [Domain] Entity [Domain] Entity Filer Category Entity Filer Category Entity Registrant Name Entity Registrant Name Equity [Abstract] Equity [Abstract] Equity Component [Domain] Equity Component [Domain] Amount per share or per unit assigned to the consideration received of equity securities issued for development stage entities. Development Stage Entities, Equity Issuance, Per Share Amount Common stock issued under private placement, price per share Equity Offering Costs Equity Offering Costs Estimated offering expense Excess Principal Value Over Fair Value Excess Principal Value Over Fair Value Value of shares in excess of principal amount of Notes based on closing price Excess Tax Benefit (Tax Deficiency) From Share Based Compensation Financing Activities Excess Tax Benefit Tax Deficiency From Share Based Compensation Financing Activities Excess tax provision on stock-based awards Excess Tax Benefit (Tax Deficiency) From Share Based Compensation Operating Activities Excess Tax Benefit Tax Deficiency From Share Based Compensation Operating Activities Excess tax provision on stock-based awards Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value Measurements, Recurring and Nonrecurring [Table] Fair Value Measurements, Recurring and Nonrecurring [Table]