00000 - Document - Template Link link:presentationLink link:calculationLink link:definitionLink 100000 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 100010 - Statement - Consolidated Balance Sheets link:calculationLink link:presentationLink link:definitionLink 100020 - Statement - Consolidated Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 100030 - Statement - Consolidated Statements of Operations link:calculationLink link:presentationLink link:definitionLink 100040 - Statement - Consolidated Statements Of Stockholders' Equity (Deficit) link:calculationLink link:presentationLink link:definitionLink 100050 - Statement - Consolidated Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 100060 - Disclosure - Nature of Business and Basis of Presentation link:calculationLink link:presentationLink link:definitionLink 100070 - Disclosure - Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 100080 - Disclosure - Intangible Asset link:calculationLink link:presentationLink link:definitionLink 100090 - Disclosure - Inventory link:calculationLink link:presentationLink link:definitionLink 100100 - Disclosure - Property, Plant and Equipment link:calculationLink link:presentationLink link:definitionLink 100110 - Disclosure - Accrued Expenses and Other Current Liabilities link:calculationLink link:presentationLink link:definitionLink 100120 - Disclosure - Debt link:calculationLink link:presentationLink link:definitionLink 100130 - Disclosure - Commitments and Contingencies link:calculationLink link:presentationLink link:definitionLink 100140 - Disclosure - Equity link:calculationLink link:presentationLink link:definitionLink 100150 - Disclosure - Income Taxes link:calculationLink link:presentationLink link:definitionLink 100160 - Disclosure - Stock Incentive Plans and Stock Based Compensation link:calculationLink link:presentationLink link:definitionLink 100170 - Disclosure - Defined Contribution Plan link:calculationLink link:presentationLink link:definitionLink 100180 - Disclosure - Quarterly Summarized Financial Information (Unaudited) link:calculationLink link:presentationLink link:definitionLink 100190 - Disclosure - Co-Promotion Agreement link:calculationLink link:presentationLink link:definitionLink 100200 - Disclosure - Revenue Recognition link:calculationLink link:presentationLink link:definitionLink 100210 - Disclosure - Development, Commercialization and Supply Agreements link:calculationLink link:presentationLink link:definitionLink 100220 - Disclosure - Subsequent Events link:calculationLink link:presentationLink link:definitionLink 100230 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 100240 - Disclosure - Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 100250 - Disclosure - Intangible Asset (Tables) link:calculationLink link:presentationLink link:definitionLink 100260 - Disclosure - Inventory (Tables) link:calculationLink link:presentationLink link:definitionLink 100270 - Disclosure - Property, Plant and Equipment (Tables) link:calculationLink link:presentationLink link:definitionLink 100280 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) link:calculationLink link:presentationLink link:definitionLink 100290 - Disclosure - Commitments and Contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 100300 - Disclosure - Income Taxes (Tables) link:calculationLink link:presentationLink link:definitionLink 100310 - Disclosure - Stock Incentive Plans and Stock Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 100320 - Disclosure - Quarterly Summarized Financial Information (Unaudited) (Tables) link:calculationLink link:presentationLink link:definitionLink 100330 - Disclosure - Revenue Recognition (Tables) link:calculationLink link:presentationLink link:definitionLink 100340 - Disclosure - Development, Commercialization and Supply Agreements (Tables) link:calculationLink link:presentationLink link:definitionLink 100350 - Disclosure - Nature of Business and Basis of Presentation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100360 - Disclosure - Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100370 - Disclosure - Summary of Impact of Accounts Receivable Reserves on Gross Trade Accounts Receivable Balances (Detail) link:calculationLink link:presentationLink link:definitionLink 100380 - Disclosure - Summary of Estimated Useful Lives, by Asset Classification (Detail) link:calculationLink link:presentationLink link:definitionLink 100390 - Disclosure - Calculation of Net Loss and Number of Shares Used to Compute Basic and Diluted Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 100400 - Disclosure - Anti-Dilutive Securities Not Included in the Computation of Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 100410 - Disclosure - Assets and Liability Measured at Fair Value on Recurring Basis (Detail) link:calculationLink link:presentationLink link:definitionLink 100420 - Disclosure - Carrying Amounts and Estimated Fair Values of Debt Instruments (Detail) link:calculationLink link:presentationLink link:definitionLink 100430 - Disclosure - Intangible Asset - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100440 - Disclosure - Intangible Asset (Detail) link:calculationLink link:presentationLink link:definitionLink 100450 - Disclosure - Intangible Asset Estimated Amortization Expense (Detail) link:calculationLink link:presentationLink link:definitionLink 100460 - Disclosure - Inventory - Schedule of Inventory (Detail) link:calculationLink link:presentationLink link:definitionLink 100470 - Disclosure - Property Plant and Equipment (Detail) link:calculationLink link:presentationLink link:definitionLink 100480 - Disclosure - Property Plant and Equipment - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100490 - Disclosure - Accrued Expenses and Other Current Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100500 - Disclosure - Debt - Long-Term Debt from Royalty-Bearing Instrument-December 2012 Financing - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100510 - Disclosure - Debt - January 2012, May 2014, and November 2015 Exchangeable Senior Notes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100520 - Disclosure - Debt - January 2017 Exchangeable Senior Notes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100530 - Disclosure - Future Minimum Lease Payments under Operating Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 100540 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100550 - Disclosure - Equity - Preferred Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100560 - Disclosure - Equity - Common Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100570 - Disclosure - Equity - Incentive Equity Awards - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100580 - Disclosure - Income Taxes - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100590 - Disclosure - Reconciliation of Total Amounts of Unrecognized Tax Benefits (Detail) link:calculationLink link:presentationLink link:definitionLink 100600 - Disclosure - Jurisdictions the Company Remains Subject to Tax Examinations (Detail) link:calculationLink link:presentationLink link:definitionLink 100610 - Disclosure - Components of Loss from Operations Before Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 100620 - Disclosure - Benefit from Income Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 100630 - Disclosure - Difference between Benefit from Income Taxes and Amount Computed by Applying Statutory Income Tax Rate to Income Before Taxes (Detail) link:calculationLink link:presentationLink link:definitionLink 100640 - Disclosure - Income Taxes Effect of Each Type of Temporary Difference Comprising Net Differed Tax Asset (Detail) link:calculationLink link:presentationLink link:definitionLink 100650 - Disclosure - Valuation Allowance (Detail) link:calculationLink link:presentationLink link:definitionLink 100660 - Disclosure - Stock Incentive Plans and Stock Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100670 - Disclosure - Stock Option Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100680 - Disclosure - Assumptions Used to Estimate Fair Value of Share-Based Payment Awards (Detail) link:calculationLink link:presentationLink link:definitionLink 100690 - Disclosure - Restricted Stock Unit Activity (Detail) link:calculationLink link:presentationLink link:definitionLink 100700 - Disclosure - Stock-Based Compensation Expense Related to Option Awards (Detail) link:calculationLink link:presentationLink link:definitionLink 100710 - Disclosure - Defined Contribution Plans - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100720 - Disclosure - Quarterly Summarized Financial Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100730 - Disclosure - Co-Promotion Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100740 - Disclosure - Revenue Recognition - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100750 - Disclosure - Summarize Activity of the Net Product Revenue Allowance and Reserve Categories (Detail) link:calculationLink link:presentationLink link:definitionLink 100760 - Disclosure - Development, Commercialization and Supply Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100770 - Disclosure - Development, Commercialization and Supply Agreement - Additional Information1 (Detail) link:calculationLink link:presentationLink link:definitionLink 100770 - Disclosure - Development, Commercialization and Supply Agreement - Additional Information1 (Detail) link:calculationLink link:presentationLink link:definitionLink 100780 - Disclosure - Development, Commercialization and Supply Agreement - Changes in Balances of Contract Assets and Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100790 - Disclosure - Development, Commercialization and Supply Agreement - Recognized Revenues Changes in Contract Asset and Contract Liability Balances (Detail) link:calculationLink link:presentationLink link:definitionLink 100800 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink